OSCAR (gene)

Osteoclast associated, immunoglobulin-like receptor
Identifiers
Symbols	OSCAR; MGC33613; PIGR3
External IDs	OMIM: 606862 MGI: 2179720 HomoloGene: 77042 GeneCards: OSCAR Gene
Gene Ontology Molecular function • receptor activity Cellular component • extracellular region • plasma membrane • integral to membrane Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	126014	232790
Ensembl	ENSG00000170909	ENSMUSG00000054594
UniProt	Q8IYS5	n/a
RefSeq (mRNA)	NM_130771.3	NM_175632.2
RefSeq (protein)	NP_570127.2	NP_783440.1
Location (UCSC)	Chr 19: 54.6 – 54.61 Mb	Chr 7: 3.56 – 3.57 Mb
PubMed search	[1]	[2]

Osteoclast-associated immunoglobulin-like receptor is a protein that in humans is encoded by the OSCAR gene.^[1][2]

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[2]

References

1. ^ Kim N, Takami M, Rho J, Josien R, Choi Y (Jan 2002). "A novel member of the leukocyte receptor complex regulates osteoclast differentiation". J Exp Med 195 (2): 201–9. doi:10.1084/jem.20011681. PMC 2193610. PMID 11805147. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193610. 
2. ^ ^{a b} "Entrez Gene: OSCAR osteoclast-associated receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=126014. 

Further reading

• Pupello DF, Lipton M, Shumway NE (1976). "An unusual case of a bullet embolus.". The Journal of the Florida Medical Association 62 (11): 51. PMID 1185147. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Merck E, Gaillard C, Gorman DM, et al. (2004). "OSCAR is an FcRgamma-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells.". Blood 104 (5): 1386–95. doi:10.1182/blood-2004-03-0850. PMID 15155468. 
• Merck E, de Saint-Vis B, Scuiller M, et al. (2005). "Fc receptor gamma-chain activation via hOSCAR induces survival and maturation of dendritic cells and modulates Toll-like receptor responses.". Blood 105 (9): 3623–32. doi:10.1182/blood-2004-07-2809. PMID 15650060. 
• Tenca C, Merlo A, Merck E, et al. (2005). "CD85j (leukocyte Ig-like receptor-1/Ig-like transcript 2) inhibits human osteoclast-associated receptor-mediated activation of human dendritic cells.". J. Immunol. 174 (11): 6757–63. PMID 15905516. 
• Kim GS, Koh JM, Chang JS, et al. (2005). "Association of the OSCAR promoter polymorphism with BMD in postmenopausal women.". J. Bone Miner. Res. 20 (8): 1342–8. doi:10.1359/JBMR.050320. PMID 16007331. 
• Kim K, Kim JH, Lee J, et al. (2005). "Nuclear factor of activated T cells c1 induces osteoclast-associated receptor gene expression during tumor necrosis factor-related activation-induced cytokine-mediated osteoclastogenesis.". J. Biol. Chem. 280 (42): 35209–16. doi:10.1074/jbc.M505815200. PMID 16109714. 
• Merck E, Gaillard C, Scuiller M, et al. (2006). "Ligation of the FcR gamma chain-associated human osteoclast-associated receptor enhances the proinflammatory responses of human monocytes and neutrophils.". J. Immunol. 176 (5): 3149–56. PMID 16493074.