- RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated), also known as RASGRP2, is a human
gene .cite web | title = Entrez Gene: RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10235| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Two alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been reported.cite web | title = Entrez Gene: RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10235| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kedra D, Seroussi E, Fransson I, "et al." |title=The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. |journal=Hum. Genet. |volume=100 |issue= 5-6 |pages= 611–9 |year= 1997 |pmid= 9341881 |doi=
*cite journal | author=Kawasaki H, Springett GM, Toki S, "et al." |title=A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 22 |pages= 13278–83 |year= 1998 |pmid= 9789079 |doi=
*cite journal | author=Clyde-Smith J, Silins G, Gartside M, "et al." |title=Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 32260–7 |year= 2000 |pmid= 10918068 |doi= 10.1074/jbc.M006087200
*cite journal | author=Guo FF, Kumahara E, Saffen D |title=A CalDAG-GEFI/Rap1/B-Raf cassette couples M(1) muscarinic acetylcholine receptors to the activation of ERK1/2. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25568–81 |year= 2001 |pmid= 11292831 |doi= 10.1074/jbc.M101277200
*cite journal | author=Toki S, Kawasaki H, Tashiro N, "et al." |title=Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons. |journal=J. Comp. Neurol. |volume=437 |issue= 4 |pages= 398–407 |year= 2001 |pmid= 11503142 |doi=
*cite journal | author=Eto K, Murphy R, Kerrigan SW, "et al." |title=Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 20 |pages= 12819–24 |year= 2002 |pmid= 12239348 |doi= 10.1073/pnas.202380099
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Katagiri K, Shimonaka M, Kinashi T |title=Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11875–81 |year= 2004 |pmid= 14702343 |doi= 10.1074/jbc.M310717200
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406PBB_Controls
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