ADAMTS

ADAMTS

ADAMTS (A Disintegrin And Metalloproteinase with Thrombospondin Motifs) is a family of peptidases. 19 members of this family have been identified in humans. Known functions of the ADAMTS proteases include processing of procollagens and von Willebrand factor as well as cleavage of aggrecan, versican, brevican and neurocan. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration.[1]

Family members are:

See also

  • A disintegrin and metalloproteinase (ADAM) family

References

  1. ^ Apte, Suneel (2004). "A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family". The international Journal of Biochemistry and Cell Biology: 981–985. PMID 20036837. 
  2. ^ METH-2 silencing and promoter hypermethylation in NSCLC
v · Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins
Alpha secretases (ADAM9 · ADAM10 · ADAM17 · ADAM19) · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13
Matrix metalloproteinases
Collagenases (MMP1, MMP8) · Gelatinases (MMP2, MMP9) · MMP3 · MMP7 · MMP10 · MMP11 · MMP12 · MMP13 · MMP14 · MMP15 · MMP16 · MMP17 · MMP19 · MMP20 · MMP21 · MMP23A · MMP23B · MMP24 · MMP25 · MMP26 · MMP27 · MMP28
Other
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

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Look at other dictionaries:

  • ADAMTSL1 — ADAMTS like 1, also known as ADAMTSL1, is a human gene.cite web | title = Entrez Gene: ADAMTSL1 ADAMTS like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=92949| accessdate = ] PBB Summary section title …   Wikipedia

  • ADAMTSL4 — ADAMTS like 4, also known as ADAMTSL4, is a human gene.cite web | title = Entrez Gene: ADAMTSL4 ADAMTS like 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=54507| accessdate = ] PBB Summary section title …   Wikipedia

  • ADAMTS4 — ADAM metallopeptidase with thrombospondin type 1 motif, 4, also known as ADAMTS4, is a human gene. PBB Summary section title = summary text = This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin… …   Wikipedia

  • ADAMTS1 — ADAM metallopeptidase with thrombospondin type 1 motif, 1 Available structures …   Wikipedia

  • ADAMTS13 — ( a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 ) also known as von Willebrand factor cleaving protease (VWFCP) is a zinc containing metalloprotease enzyme that cleaves von Willebrand factor (vWf), a large… …   Wikipedia

  • ADAMTS3 — ADAM metallopeptidase with thrombospondin type 1 motif, 3, also known as ADAMTS3, is a human gene.cite web | title = Entrez Gene: ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db …   Wikipedia

  • ADAMTS9 — ADAM metallopeptidase with thrombospondin type 1 motif, 9, also known as ADAMTS9, is a human gene.cite web | title = Entrez Gene: ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db …   Wikipedia

  • ADAMTS8 — ADAM metallopeptidase with thrombospondin type 1 motif, 8, also known as ADAMTS8, is a human gene.cite web | title = Entrez Gene: ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db …   Wikipedia

  • ADAMTS10 — ADAM metallopeptidase with thrombospondin type 1 motif, 10, also known as ADAMTS10, is a human gene.cite web | title = Entrez Gene: ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10| url =… …   Wikipedia

  • Thrombocytopenia — Infobox Disease Name = Thrombocytopenia Caption = DiseasesDB = 27522 ICD10 = ICD10|D|69|6|d|65, ICD10|P|61|0|p|50 ICD9 = ICD9|287.3, ICD9|287.4, ICD9|287.5 ICDO = OMIM = 188000 OMIM mult = OMIM2|313900 MedlinePlus = 000586 eMedicineSubj =… …   Wikipedia

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