CA8

CA8

Carbonic anhydrase VIII, also known as CA8, is a human gene.cite web | title = Entrez Gene: CA8 carbonic anhydrase VIII| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=767| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form.cite web | title = Entrez Gene: CA8 carbonic anhydrase VIII| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=767| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bergenhem NC, Sait SS, Eddy RL, "et al." |title=Assignment of the gene for human carbonic anhydrase VIII(CA8) to chromosome 8q11-->q12. |journal=Cytogenet. Cell Genet. |volume=71 |issue= 3 |pages= 299–300 |year= 1995 |pmid= 7587398 |doi=
*cite journal | author=Kelly C, Nógrádi A, Walker R, "et al." |title=Lurching, reeling, waddling and staggering in mice--is carbonic anhydrase (CA) VIII a candidate gene? |journal=Biochem. Soc. Trans. |volume=22 |issue= 3 |pages= 359S |year= 1995 |pmid= 7821612 |doi=
*cite journal | author=Skaggs LA, Bergenhem NC, Venta PJ, Tashian RE |title=The deduced amino acid sequence of human carbonic anhydrase-related protein (CARP) is 98% identical to the mouse homologue. |journal=Gene |volume=126 |issue= 2 |pages= 291–2 |year= 1993 |pmid= 8482548 |doi=
*cite journal | author=Sjöblom B, Elleby B, Wallgren K, "et al." |title=Two point mutations convert a catalytically inactive carbonic anhydrase-related protein (CARP) to an active enzyme. |journal=FEBS Lett. |volume=398 |issue= 2-3 |pages= 322–5 |year= 1997 |pmid= 8977131 |doi=
*cite journal | author=Taniuchi K, Nishimori I, Takeuchi T, "et al." |title=Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain. |journal=Neuroscience |volume=112 |issue= 1 |pages= 93–9 |year= 2002 |pmid= 12044474 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Akisawa Y, Nishimori I, Taniuchi K, "et al." |title=Expression of carbonic anhydrase-related protein CA-RP VIII in non-small cell lung cancer. |journal=Virchows Arch. |volume=442 |issue= 1 |pages= 66–70 |year= 2003 |pmid= 12536316 |doi= 10.1007/s00428-002-0721-y
*cite journal | author=Hirota J, Ando H, Hamada K, Mikoshiba K |title=Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1. |journal=Biochem. J. |volume=372 |issue= Pt 2 |pages= 435–41 |year= 2003 |pmid= 12611586 |doi= 10.1042/BJ20030110
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Nishikata M, Nishimori I, Taniuchi K, "et al." |title=Carbonic anhydrase-related protein VIII promotes colon cancer cell growth. |journal=Mol. Carcinog. |volume=46 |issue= 3 |pages= 208–14 |year= 2007 |pmid= 17219437 |doi= 10.1002/mc.20264

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