NFKBIL1

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
Identifiers
Symbols	NFKBIL1; IKBL; LST1; NFKBIL
External IDs	OMIM: 601022 MGI: 1340031 HomoloGene: 3671 GeneCards: NFKBIL1 Gene
Gene Ontology Molecular function • protein binding Biological process • cytoplasmic sequestering of transcription factor Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4795	18038
Ensembl	ENSG00000204498	ENSMUSG00000042419
UniProt	Q9UBC1	Q3V006
RefSeq (mRNA)	NM_001144961.1	NM_010909.4
RefSeq (protein)	NP_001138433.1	NP_035039.1
Location (UCSC)	Chr 6: 31.51 – 31.53 Mb	Chr 17: 35.36 – 35.37 Mb
PubMed search	[1]	[2]

NF-kappa-B inhibitor-like protein 1 is a protein that in humans is encoded by the NFKBIL1 gene.^[1][2]

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6.^[2]

References

1. ^ Albertella MR, Campbell RD (Oct 1994). "Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins". Hum Mol Genet 3 (5): 793–9. doi:10.1093/hmg/3.5.793. PMID 8081366. 
2. ^ ^{a b} "Entrez Gene: NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4795. 

Further reading

• Iris FJ, Bougueleret L, Prieur S, et al. (1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment.". Nat. Genet. 3 (2): 137–45. doi:10.1038/ng0293-137. PMID 8499947. 
• Shiina T, Tamiya G, Oka A, et al. (1998). "Nucleotide sequencing analysis of the 146-kilobase segment around the IkBL and MICA genes at the centromeric end of the HLA class I region.". Genomics 47 (3): 372–82. doi:10.1006/geno.1997.5114. PMID 9480751. 
• Neville MJ, Campbell RD (1999). "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.". J. Immunol. 162 (8): 4745–54. PMID 10202016. 
• Allcock RJ, Christiansen FT, Price P (1999). "The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15.". Immunogenetics 49 (7–8): 660–5. doi:10.1007/s002510050662. PMID 10369924. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Okamoto K, Makino S, Yoshikawa Y, et al. (2003). "Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis". Am. J. Hum. Genet. 72 (2): 303–12. doi:10.1086/346067. PMC 379224. PMID 12509789. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=379224. 
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404. 
• Lin CH, Cho CL, Tsai WC, et al. (2006). "Inhibitors of kB-like gene polymorphisms in rheumatoid arthritis". Immunol. Lett. 105 (2): 193–7. doi:10.1016/j.imlet.2006.03.003. PMID 16644022. 
• Glas J, Török HP, Tonenchi L, et al. (2007). "Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes". Inflamm. Bowel Dis. 12 (7): 606–11. doi:10.1097/01.ibd.0000225346.23765.6b. PMID 16804398. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 
• Koch W, Hoppmann P, Michou E, et al. (2007). "Association of variants in the BAT1-NFKBIL1-LTA genomic region with protection against myocardial infarction in Europeans". Hum. Mol. Genet. 16 (15): 1821–7. doi:10.1093/hmg/ddm130. PMID 17517687. 
• Ramasawmy R, Faé KC, Cunha-Neto E, et al. (2007). "Variants in the promoter region of IKBL/NFKBIL1 gene may mark susceptibility to the development of chronic Chagas' cardiomyopathy among Trypanosoma cruzi-infected individuals". Mol. Immunol. 45 (1): 283–8. doi:10.1016/j.molimm.2007.04.015. PMID 17544510. 
• Kariz S, Milutinović A, Bregar D, et al. (2007). "The interleukin-1 receptor antagonist gene and the inhibitor of kappa B-like protein gene polymorphisms are not associated with myocardial infarction in Slovene population with type 2 diabetes". Collegium antropologicum 31 (2): 503–7. PMID 17847930. 

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