PDE10A

PDE10A
Phosphodiesterase 10A

PDB rendering based on 2o8h.
Identifiers
Symbols PDE10A; FLJ11894; FLJ25677; HSPDE10A
External IDs OMIM610652 MGI1345143 HomoloGene4852 GeneCards: PDE10A Gene
EC number 3.1.4.17
RNA expression pattern
PBB GE PDE10A 211170 s at tn.png
PBB GE PDE10A 211171 s at tn.png
PBB GE PDE10A 205501 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10846 23984
Ensembl ENSG00000112541 ENSMUSG00000023868
UniProt Q9Y233 Q8CA95
RefSeq (mRNA) NM_001130690.1 NM_011866.2
RefSeq (protein) NP_001124162.1 NP_035996.2
Location (UCSC) Chr 6:
165.74 – 166.08 Mb
Chr 17:
8.72 – 9.18 Mb
PubMed search [1] [2]

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an enzyme that in humans is encoded by the PDE10A gene.[1][2]

Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.[2][3]

Inhibitors

  • PF-2545920[4]

References

  1. ^ Fujishige K, Kotera J, Michibata H, Yuasa K, Takebayashi S, Okumura K, Omori K (Jul 1999). "Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)". J Biol Chem 274 (26): 18438–45. doi:10.1074/jbc.274.26.18438. PMID 10373451. 
  2. ^ a b "Entrez Gene: PDE10A phosphodiesterase 10A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10846. 
  3. ^ Fujishige K, Kotera J, Yuasa K, Omori K (October 2000). "The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains". Eur. J. Biochem. 267 (19): 5943–51. doi:10.1046/j.1432-1327.2000.01661.x. PMID 10998054. 
  4. ^ PMID 19630403

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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