STK24

Serine/threonine kinase 24 (STE20 homolog, yeast), also known as STK24, is a human gene.cite web | title = Entrez Gene: STK24 serine/threonine kinase 24 (STE20 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8428| accessdate = ]

PBB_Summary
section_title =
summary_text = The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000). [supplied by OMIM] cite web | title = Entrez Gene: STK24 serine/threonine kinase 24 (STE20 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8428| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schinkmann K, Blenis J |title=Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements. |journal=J. Biol. Chem. |volume=272 |issue= 45 |pages= 28695–703 |year= 1997 |pmid= 9353338 |doi=
*cite journal | author=Zhou TH, Ling K, Guo J, "et al." |title=Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2513–9 |year= 2000 |pmid= 10644707 |doi=
*cite journal | author=Christian SL, McDonough J, Liu Cy CY, "et al." |title=An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia. |journal=Genomics |volume=79 |issue= 5 |pages= 635–56 |year= 2002 |pmid= 11991713 |doi= 10.1006/geno.2002.6765
*cite journal | author=Huang CY, Wu YM, Hsu CY, "et al." |title=Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34367–74 |year= 2002 |pmid= 12107159 |doi= 10.1074/jbc.M202468200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Lee WS, Hsu CY, Wang PL, "et al." |title=Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3. |journal=FEBS Lett. |volume=572 |issue= 1-3 |pages= 41–5 |year= 2004 |pmid= 15304321 |doi= 10.1016/j.febslet.2004.07.007
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Stegert MR, Hergovich A, Tamaskovic R, "et al." |title=Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. |journal=Mol. Cell. Biol. |volume=25 |issue= 24 |pages= 11019–29 |year= 2006 |pmid= 16314523 |doi= 10.1128/MCB.25.24.11019-11029.2005
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Lu TJ, Lai WY, Huang CY, "et al." |title=Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST. |journal=J. Biol. Chem. |volume=281 |issue= 50 |pages= 38405–17 |year= 2007 |pmid= 17046825 |doi= 10.1074/jbc.M605035200
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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