PPP1R12B

Protein phosphatase 1, regulatory (inhibitor) subunit 12B, also known as PPP1R12B, is a human gene.cite web | title = Entrez Gene: PPP1R12B protein phosphatase 1, regulatory (inhibitor) subunit 12B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4660| accessdate = ]

PBB_Summary
section_title =
summary_text = Myosin light chain phosphatase (MLCP) consists of three subunits- catalytic subunit, large subunit/myosin binding subunit (MBS) and small subunit (sm-M20). This gene is a multi-functional gene which encodes both MBS and sm-M20. MLCP regulates myosins and the dephosphorylation is enhanced by the presence of MBS. The sm-M20 is suggested to play a regulatory role in muscle contraction by binding to MBS. MBS is also encoded by another gene, myosin light chain phosphatase target subunit 1. sm-M20 shows higher binding affinity to this gene product than to myosin light chain phosphatase target subunit 2-MBS even though the two MBS proteins are highly similar. Although both MBSs increase the activity of MLCP, myosin light chain phosphatase target subunit 1-MBS is a more efficient activator. There are four alternatively spliced transcript variants described; two alter the MBS coding region and two alter the sm-M20 coding region of this gene.cite web | title = Entrez Gene: PPP1R12B protein phosphatase 1, regulatory (inhibitor) subunit 12B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4660| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Somlyo AP, Wu X, Walker LA, Somlyo AV |title=Pharmacomechanical coupling: the role of calcium, G-proteins, kinases and phosphatases. |journal=Rev. Physiol. Biochem. Pharmacol. |volume=134 |issue= |pages= 201–34 |year= 1999 |pmid= 10087910 |doi=
*cite journal | author=Seki N, Ohira M, Nagase T, "et al." |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=4 |issue= 5 |pages= 345–9 |year= 1998 |pmid= 9455484 |doi=
*cite journal | author=Fujioka M, Takahashi N, Odai H, "et al." |title=A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping. |journal=Genomics |volume=49 |issue= 1 |pages= 59–68 |year= 1998 |pmid= 9570949 |doi= 10.1006/geno.1998.5222
*cite journal | author=Moorhead G, Johnson D, Morrice N, Cohen P |title=The major myosin phosphatase in skeletal muscle is a complex between the beta-isoform of protein phosphatase 1 and the MYPT2 gene product. |journal=FEBS Lett. |volume=438 |issue= 3 |pages= 141–4 |year= 1998 |pmid= 9827534 |doi=
*cite journal | author=Somlyo AP |title=Kinases, myosin phosphatase and Rho proteins: curiouser and curiouser. |journal=J. Physiol. (Lond.) |volume=516 ( Pt 3) |issue= |pages= 630 |year= 1999 |pmid= 10200412 |doi=
*cite journal | author=Arimura T, Suematsu N, Zhou YB, "et al." |title=Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6073–82 |year= 2001 |pmid= 11067852 |doi= 10.1074/jbc.M008566200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bannert N, Vollhardt K, Asomuddinov B, "et al." |title=PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 42190–9 |year= 2004 |pmid= 12923170 |doi= 10.1074/jbc.M306669200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Okamoto R, Kato T, Mizoguchi A, "et al." |title=Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart. |journal=Cell. Signal. |volume=18 |issue= 9 |pages= 1408–16 |year= 2007 |pmid= 16431080 |doi= 10.1016/j.cellsig.2005.11.001
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

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