IARS

IARS

Isoleucyl-tRNA synthetase, also known as IARS, is a human gene.cite web | title = Entrez Gene: IARS isoleucyl-tRNA synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3376| accessdate = ]

PBB_Summary
section_title =
summary_text = Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs.cite web | title = Entrez Gene: IARS isoleucyl-tRNA synthetase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3376| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Norcum MT |title=Structural analysis of the high molecular mass aminoacyl-tRNA synthetase complex. Effects of neutral salts and detergents. |journal=J. Biol. Chem. |volume=266 |issue= 23 |pages= 15398–405 |year= 1991 |pmid= 1651330 |doi=
*cite journal | author=Nichols RC, Raben N, Boerkoel CF, Plotz PH |title=Human isoleucyl-tRNA synthetase: sequence of the cDNA, alternative mRNA splicing, and the characteristics of an unusually long C-terminal extension. |journal=Gene |volume=155 |issue= 2 |pages= 299–304 |year= 1995 |pmid= 7721108 |doi=
*cite journal | author=Shiba K, Suzuki N, Shigesada K, "et al." |title=Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 16 |pages= 7435–9 |year= 1994 |pmid= 8052601 |doi=
*cite journal | author=Nichols RC, Blinder J, Pai SI, "et al." |title=Assignment of two human autoantigen genes-isoleucyl-tRNA synthetase locates to 9q21 and lysyl-tRNA synthetase locates to 16q23-q24. |journal=Genomics |volume=36 |issue= 1 |pages= 210–3 |year= 1997 |pmid= 8812440 |doi= 10.1006/geno.1996.0449
*cite journal | author=Rho SB, Lee KH, Kim JW, "et al." |title=Interaction between human tRNA synthetases involves repeated sequence elements. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 19 |pages= 10128–33 |year= 1996 |pmid= 8816763 |doi=
*cite journal | author=Degoul F, Brulé H, Cepanec C, "et al." |title=Isoleucylation properties of native human mitochondrial tRNAIle and tRNAIle transcripts. Implications for cardiomyopathy-related point mutations (4269, 4317) in the tRNAIle gene. |journal=Hum. Mol. Genet. |volume=7 |issue= 3 |pages= 347–54 |year= 1998 |pmid= 9466989 |doi=
*cite journal | author=Rho SB, Lee JS, Jeong EJ, "et al." |title=A multifunctional repeated motif is present in human bifunctional tRNA synthetase. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 11267–73 |year= 1998 |pmid= 9556618 |doi=
*cite journal | author=Quevillon S, Robinson JC, Berthonneau E, "et al." |title=Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. |journal=J. Mol. Biol. |volume=285 |issue= 1 |pages= 183–95 |year= 1999 |pmid= 9878398 |doi= 10.1006/jmbi.1998.2316
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Humphray SJ, Oliver K, Hunt AR, "et al." |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • IARS — International Anesthesia Research Society (Medical) …   Abbreviations dictionary

  • IARS — image archival and retrieval system …   Medical dictionary

  • IARS — Independent Air Revitalization System NASA …   Acronyms

  • IARS — Independent Air Revitalization System ( > NASA Acronym List ) …   Acronyms von A bis Z

  • IARS — • image archival and retrieval system …   Dictionary of medical acronyms & abbreviations

  • OpenAnesthesia — OpenAnesthesia, a website sponsored by the International Anesthesia Research Society (IARS), is an online multimodal toolkit specifically designed to advance graduate medical education (GME) in anesthesia. Dr. Edward Nemergut [1], Associate… …   Wikipedia

  • Topol-M — à Moscou …   Wikipédia en Français

  • U.C.L.A. — Royce Hall – Hauptgebäude der UCLA Die University of California, Los Angeles (UCLA) wurde 1919 gegründet und ist der zweitälteste Campus der University of California. Die Universität befindet sich seit 1927 in Westwood Village in Los Angeles,… …   Deutsch Wikipedia

  • UCLA — Royce Hall – Hauptgebäude der UCLA Die University of California, Los Angeles (UCLA) wurde 1919 gegründet und ist der zweitälteste Campus der University of California. Die Universität befindet sich seit 1927 in Westwood Village in Los Angeles,… …   Deutsch Wikipedia

  • UC Los Angeles — Royce Hall – Hauptgebäude der UCLA Die University of California, Los Angeles (UCLA) wurde 1919 gegründet und ist der zweitälteste Campus der University of California. Die Universität befindet sich seit 1927 in Westwood Village in Los Angeles,… …   Deutsch Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”