TRIM23

Tripartite motif-containing 23, also known as TRIM23, is a human gene.cite web | title = Entrez Gene: TRIM23 tripartite motif-containing 23| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=373| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phospholipase D activation. Three alternatively spliced transcript variants for this gene have been described.cite web | title = Entrez Gene: TRIM23 tripartite motif-containing 23| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=373| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mishima K, Tsuchiya M, Nightingale MS, "et al." |title=ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl-terminal ADP-ribosylation factor domain. |journal=J. Biol. Chem. |volume=268 |issue= 12 |pages= 8801–7 |year= 1993 |pmid= 8473324 |doi=
*cite journal | author=Vitale N, Moss J, Vaughan M |title=ARD1, a 64-kDa bifunctional protein containing an 18-kDa GTP-binding ADP-ribosylation factor domain and a 46-kDa GTPase-activating domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 5 |pages= 1941–4 |year= 1996 |pmid= 8700863 |doi=
*cite journal | author=Vitale N, Moss J, Vaughan M |title=Characterization of a GDP dissociation inhibitory region of ADP-ribosylation factor domain protein ARD1. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25077–82 |year= 1997 |pmid= 9312116 |doi=
*cite journal | author=Vitale N, Moss J, Vaughan M |title=Molecular characterization of the GTPase-activating domain of ADP-ribosylation factor domain protein 1 (ARD1). |journal=J. Biol. Chem. |volume=273 |issue= 5 |pages= 2553–60 |year= 1998 |pmid= 9446556 |doi=
*cite journal | author=Vitale N, Horiba K, Ferrans VJ, "et al." |title=Localization of ADP-ribosylation factor domain protein 1 (ARD1) in lysosomes and Golgi apparatus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8613–8 |year= 1998 |pmid= 9671726 |doi=
*cite journal | author=Vitale N, Pacheco-Rodriguez G, Ferrans VJ, "et al." |title=Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1). |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21331–9 |year= 2000 |pmid= 10748148 |doi= 10.1074/jbc.M909642199
*cite journal | author=Vitale N, Ferrans VJ, Moss J, Vaughan M |title=Identification of lysosomal and Golgi localization signals in GAP and ARF domains of ARF domain protein 1. |journal=Mol. Cell. Biol. |volume=20 |issue= 19 |pages= 7342–52 |year= 2000 |pmid= 10982851 |doi=
*cite journal | author=Reymond A, Meroni G, Fantozzi A, "et al." |title=The tripartite motif family identifies cell compartments. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2140–51 |year= 2001 |pmid= 11331580 |doi= 10.1093/emboj/20.9.2140
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Vichi A, Payne DM, Pacheco-Rodriguez G, "et al." |title=E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 6 |pages= 1945–50 |year= 2005 |pmid= 15684077 |doi= 10.1073/pnas.0409800102
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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