C13orf15

Response gene to complement 32, also known as RGC32, is a human gene.cite web | title = Entrez Gene: RGC32 response gene to complement 32| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28984| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression.cite web | title = Entrez Gene: RGC32 response gene to complement 32| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28984| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Fosbrink M, Niculescu F, Rus H |title=The role of c5b-9 terminal complement complex in activation of the cell cycle and transcription. |journal=Immunol. Res. |volume=31 |issue= 1 |pages= 37–46 |year= 2005 |pmid= 15591621 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Badea TC, Niculescu FI, Soane L, "et al." |title=Molecular cloning and characterization of RGC-32, a novel gene induced by complement activation in oligodendrocytes. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26977–81 |year= 1998 |pmid= 9756947 |doi=
*cite journal | author=Badea T, Niculescu F, Soane L, "et al." |title=RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 502–8 |year= 2002 |pmid= 11687586 |doi= 10.1074/jbc.M109354200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Dunham A, Matthews LH, Burton J, "et al." |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fosbrink M, Cudrici C, Niculescu F, "et al." |title=Overexpression of RGC-32 in colon cancer and other tumors. |journal=Exp. Mol. Pathol. |volume=78 |issue= 2 |pages= 116–22 |year= 2005 |pmid= 15713436 |doi= 10.1016/j.yexmp.2004.11.001
*cite journal | author=Tanaka T, Takada H, Nomura A, "et al." |title=Distinct gene expression patterns of peripheral blood cells in hyper-IgE syndrome. |journal=Clin. Exp. Immunol. |volume=140 |issue= 3 |pages= 524–31 |year= 2005 |pmid= 15932515 |doi= 10.1111/j.1365-2249.2005.02805.x
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Saigusa K, Imoto I, Tanikawa C, "et al." |title=RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. |journal=Oncogene |volume=26 |issue= 8 |pages= 1110–21 |year= 2007 |pmid= 17146433 |doi= 10.1038/sj.onc.1210148

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