CNTN4

Contactin 4, also known as CNTN4, is a human gene.cite web | title = Entrez Gene: CNTN4 contactin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=152330| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Abnormal expression of this gene has been implicated in some cases of autism. [http://www.newsdaily.com/stories/n18220544-autism-genes/]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Walsh FS, Doherty P |title=Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system. |journal=Cell Biol. Int. Rep. |volume=15 |issue= 11 |pages= 1151–66 |year= 1992 |pmid= 1838307 |doi=
*cite journal | author=Miura S, Shibata H, Furuya H, "et al." |title=The contactin 4 gene locus at 3p26 is a candidate gene of SCA16. |journal=Neurology |volume=67 |issue= 7 |pages= 1236–41 |year= 2006 |pmid= 17030759 |doi= 10.1212/01.wnl.0000238510.84932.82
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fernandez T, Morgan T, Davis N, "et al." |title=Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome. |journal=Am. J. Hum. Genet. |volume=74 |issue= 6 |pages= 1286–93 |year= 2004 |pmid= 15106122 |doi= 10.1086/421474
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Hansford LM, Smith SA, Haber M, "et al." |title=Cloning and characterization of the human neural cell adhesion molecule, CNTN4 (alias BIG-2). |journal=Cytogenet. Genome Res. |volume=101 |issue= 1 |pages= 17–23 |year= 2004 |pmid= 14571131 |doi= 10.1159/000073412
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zeng L, Zhang C, Xu J, "et al." |title=A novel splice variant of the cell adhesion molecule contactin 4 ( CNTN4) is mainly expressed in human brain. |journal=J. Hum. Genet. |volume=47 |issue= 9 |pages= 497–9 |year= 2002 |pmid= 12202991 |doi= 10.1007/s100380200073
*cite journal | author=Kamei Y, Takeda Y, Teramoto K, "et al." |title=Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. |journal=Genomics |volume=69 |issue= 1 |pages= 113–9 |year= 2001 |pmid= 11013081 |doi= 10.1006/geno.2000.6310
*cite journal | author=Mimmack ML, Saito H, Evans G, "et al." |title=A novel splice variant of the cell adhesion molecule BIG-2 is expressed in the olfactory and vomeronasal neuroepithelia. |journal=Brain Res. Mol. Brain Res. |volume=47 |issue= 1-2 |pages= 345–50 |year= 1997 |pmid= 9221934 |doi=
*cite journal | author=Yoshihara Y, Kawasaki M, Tamada A, "et al." |title=Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily. |journal=J. Neurobiol. |volume=28 |issue= 1 |pages= 51–69 |year= 1996 |pmid= 8586965 |doi= 10.1002/neu.480280106

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