Isopropamide

Isopropamide: Isopropamide

Systematic (IUPAC) name

4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium

Clinical data

MedlinePlus a694006

Pregnancy cat. ?

Legal status ? (US) Unscheduled

Routes Oral

Identifiers

CAS number 71-81-8^Y

ATC code A03AB09

PubChem CID 3775

DrugBank DB01625

ChemSpider 3643^Y

UNII 8B9I31H724^N

ChEMBL CHEMBL1201232^N

Chemical data

Formula C₂₃H₃₃N₂O_{1 ⁺}

Mol. mass 353.52092 g/mol

SMILES eMolecules & PubChem

InChI

InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1^Y
Key:JTPUMZTWMWIVPA-UHFFFAOYSA-O^Y

N(what is this?) (verify)

Isopropamide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders involving hyperacidity (gastrointestinal acidosis) and hypermotility. Chemically, it contains a quaternary ammonium group. It is most often provided as an iodide salt, but is also available as a bromide or chloride salt. It was discovered at Janssen Pharmaceutica in 1954.

References

Seeherman R, Isopropamide iodide: a long-acting anticholinergic, Del Med J. 1957 Oct;29(10):265-9.

Boss EG Jr, Buchanan GC, Effect of isopropamide iodide on basal gastric secretion in the human, Gastroenterology. 1957 Nov;33(5):730-6.

v · d · eDrugs for functional gastrointestinal disorders (A03)

Drugs for
functional bowel disorders

Antimuscarinics

Tertiary
amino group

Oxyphencyclimine • Camylofin • Mebeverine • Trimebutine • Rociverine • Dicycloverine • Dihexyverine • Difemerine • Piperidolate

Quaternary ammonium
compounds

Benzilone • Mepenzolate • Pipenzolate • Glycopyrronium • Oxyphenonium • Penthienate • Methantheline • Propantheline • Otilonium bromide • Tridihexethyl • Isopropamide • Hexocyclium • Poldine • Bevonium • Diphemanil • Tiemonium iodide • Prifinium bromide • Timepidium bromide • Fenpiverinium

Phosphodiesterase inhibitors

Papaverine • Drotaverine • Moxaverine

Acting on serotonin receptors

5-HT₃ antagonists (Alosetron, Cilansetron) • 5-HT₄ agonists (Mosapride, Prucalopride, Tegaserod)

Other

Fenpiprane • Diisopromine • Chlorbenzoxamine • Pinaverium • Fenoverine • Idanpramine • Proxazole • Alverine • Trepibutone • Isometheptene • Caroverine • Phloroglucinol • Silicones • Trimethyldiphenylpropylamine

Belladonna and derivatives
(antimuscarinics)

tertiary amines: Atropine • Hyoscyamine
quaternary ammonium compounds: Scopolamine (Butylscopolamine, Methylscopolamine) • Methylatropine • Fentonium • Cimetropium bromide

Propulsives
primarily dopamine antagonists (Metoclopramide/Bromopride, Clebopride, Domperidone, Alizapride) • 5-HT₄ agonists (Cinitapride • Cisapride)

M: DIG

anat(t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug(A2A/2B/3/4/5/6/7/14/16), blte

This drug article relating to the gastrointestinal system is a stub. You can help Wikipedia by expanding it.

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Isopropamide

References

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Systematic (IUPAC) name
4-amino-N,N-diisopropyl-N-methyl-4-oxo-3,3-diphenylbutan-1-aminium
Clinical data
MedlinePlus	a694006
Pregnancy cat.	?
Legal status	? (US) Unscheduled
Routes	Oral
Identifiers
CAS number	71-81-8^Y
ATC code	A03AB09
PubChem	CID 3775
DrugBank	DB01625
ChemSpider	3643^Y
UNII	8B9I31H724^N
ChEMBL	CHEMBL1201232^N
Chemical data
Formula	C₂₃H₃₃N₂O_{1 ⁺}
Mol. mass	353.52092 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C23H32N2O/c1-18(2)25(5,19(3)4)17-16-23(22(24)26,20-12-8-6-9-13-20)21-14-10-7-11-15-21/h6-15,18-19H,16-17H2,1-5H3,(H-,24,26)/p+1^Y Key:JTPUMZTWMWIVPA-UHFFFAOYSA-O^Y
N(what is this?) (verify)

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Isopropamide

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