OTUB1

OTUB1
OTU domain, ubiquitin aldehyde binding 1
Identifiers
Symbols OTUB1; FLJ20113; FLJ40710; MGC111158; MGC4584; OTB1; OTU1
External IDs OMIM608337 MGI2147616 HomoloGene9772 GeneCards: OTUB1 Gene
EC number 3.4.19.12
RNA expression pattern
PBB GE OTUB1 201245 s at tn.png
PBB GE OTUB1 201246 s at tn.png
PBB GE OTUB1 38710 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55611 107260
Ensembl ENSG00000167770 ENSMUSG00000024767
UniProt Q96FW1 Q7TQI3
RefSeq (mRNA) NM_017670.2 NM_134150.2
RefSeq (protein) NP_060140 NP_598911.1
Location (UCSC) Chr 11:
63.75 – 63.77 Mb
Chr 19:
7.27 – 7.28 Mb
PubMed search [1] [2]

Ubiquitin thioesterase OTUB1 also known as otubain-1 is an enzyme that in humans is encoded by the OTUB1 gene.[1][2] Alternative splicing results in multiple transcript variants.

Contents

Function

Otubain-1 is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains, being specific for lysine48 -linked polyubiquitin but not lysine63 -linked polyubiquitin.[3] It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth.[2]

Interactions

OTUB1 has been shown to interact with RNF128[4] and GNB2L1.[3]

References

  1. ^ Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1319179. 
  2. ^ a b "Entrez Gene: OTUB1 OTU domain, ubiquitin aldehyde binding 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55611. 
  3. ^ a b Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM (March 2009). "Structural basis and specificity of human otubain 1-mediated deubiquitination". Biochem. J. 418 (2): 379–90. doi:10.1042/BJ20081318. PMID 18954305. 
  4. ^ Soares L, Seroogy C, Skrenta H, Anandasabapathy N, Lovelace P, Chung CD, Engleman E, Fathman CG (January 2004). "Two isoforms of otubain 1 regulate T cell anergy via GRAIL". Nat. Immunol. 5 (1): 45–54. doi:10.1038/ni1017. PMID 14661020. 

Further reading




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  • Deubiquitinating enzyme — Deubiquitinating enzymes (DUBs) are a large group of proteases[1] (more than 60 known) that regulate ubiquitin dependent metabolic pathways by cleaving ubiquitin protein bonds. DUBs are also commonly referred to as deubiquitinating peptidases,… …   Wikipedia

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