NTNG1

Netrin G1
Identifiers
Symbols	NTNG1; KIAA0976; Lmnt1
External IDs	OMIM: 608818 HomoloGene: 8949 GeneCards: NTNG1 Gene
Gene Ontology Molecular function • protein binding Cellular component • plasma membrane • anchored to plasma membrane Biological process • multicellular organismal development • nervous system development • axonogenesis • cell differentiation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22854	80883
Ensembl	ENSG00000162631	ENSMUSG00000059857
UniProt	Q9Y2I2	n/a
RefSeq (mRNA)	NM_001113226.1	n/a
RefSeq (protein)	NP_001106697.1	n/a
Location (UCSC)	Chr 1: 107.68 – 108.03 Mb	Chr 3: 109.58 – 109.94 Mb
PubMed search	[1]	[2]

Netrin-G1 is a protein that in humans is encoded by the NTNG1 gene.^[1][2]

Netrin G1 (NTNG1) belongs to a conserved family of proteins that act as axon guidance cues during vertebrate nervous system development (Nakashiba et al., 2000).[supplied by OMIM]^[2]

References

1. ^ Nakashiba T, Ikeda T, Nishimura S, Tashiro K, Honjo T, Culotti JG, Itohara S (Sep 2000). "Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins". J Neurosci 20 (17): 6540–50. PMID 10964959. 
2. ^ ^{a b} "Entrez Gene: NTNG1 netrin G1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22854. 

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Lin JC, Ho WH, Gurney A, Rosenthal A (2004). "The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons". Nat. Neurosci. 6 (12): 1270–6. doi:10.1038/nn1148. PMID 14595443. 
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286551. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Fukasawa M, Aoki M, Yamada K, et al. (2004). "Case-control association study of human netrin G1 gene in Japanese schizophrenia". J. Med. Dent. Sci. 51 (2): 121–8. PMID 15508520. 
• Aoki-Suzuki M, Yamada K, Meerabux J, et al. (2005). "A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia". Biol. Psychiatry 57 (4): 382–93. doi:10.1016/j.biopsych.2004.11.022. PMID 15705354. 
• Borg I, Freude K, Kübart S, et al. (2005). "Disruption of Netrin G1 by a balanced chromosome translocation in a girl with Rett syndrome". Eur. J. Hum. Genet. 13 (8): 921–7. doi:10.1038/sj.ejhg.5201429. PMID 15870826. 
• Meerabux JM, Ohba H, Fukasawa M, et al. (2006). "Human netrin-G1 isoforms show evidence of differential expression". Genomics 86 (1): 112–6. doi:10.1016/j.ygeno.2005.04.004. PMID 15901489. 
• Archer HL, Evans JC, Millar DS, et al. (2006). "NTNG1 Mutations are a Rare Cause of Rett Syndrome". Am. J. Med. Genet. A 140 (7): 691–4. doi:10.1002/ajmg.a.31133. PMC 2577736. PMID 16502428. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2577736. 
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
• Nectoux J, Girard B, Bahi-Buisson N, et al. (2007). "Netrin G1 mutations are an uncommon cause of atypical Rett syndrome with or without epilepsy". Pediatr. Neurol. 37 (4): 270–4. doi:10.1016/j.pediatrneurol.2007.06.002. PMID 17903671.