COX4I2

Cytochrome c oxidase subunit IV isoform 2 (lung), also known as COX4I2, is a human gene.cite web | title = Entrez Gene: COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84701| accessdate = ]

PBB_Summary
section_title =
summary_text = Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.cite web | title = Entrez Gene: COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84701| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lynch SR, Sherman D, Copeland RA |title=Cytochrome c binding affects the conformation of cytochrome a in cytochrome c oxidase. |journal=J. Biol. Chem. |volume=267 |issue= 1 |pages= 298–302 |year= 1992 |pmid= 1309738 |doi=
*cite journal | author=Garber EA, Margoliash E |title=Interaction of cytochrome c with cytochrome c oxidase: an understanding of the high- to low-affinity transition. |journal=Biochim. Biophys. Acta |volume=1015 |issue= 2 |pages= 279–87 |year= 1990 |pmid= 2153405 |doi=
*cite journal | author=Bolli R, Nałecz KA, Azzi A |title=The interconversion between monomeric and dimeric bovine heart cytochrome c oxidase. |journal=Biochimie |volume=67 |issue= 1 |pages= 119–28 |year= 1985 |pmid= 2986725 |doi=
*cite journal | author=Michel B, Bosshard HR |title=Spectroscopic analysis of the interaction between cytochrome c and cytochrome c oxidase. |journal=J. Biol. Chem. |volume=259 |issue= 16 |pages= 10085–91 |year= 1984 |pmid= 6088481 |doi=
*cite journal | author=Hare JF, Ching E, Attardi G |title=Isolation, subunit composition, and site of synthesis of human cytochrome c oxidase. |journal=Biochemistry |volume=19 |issue= 10 |pages= 2023–30 |year= 1980 |pmid= 6246917 |doi=
*cite journal | author=Papadopoulou LC, Tsiftsoglou AS |title=Effects of hemin on apoptosis, suppression of cytochrome c oxidase gene expression, and bone-marrow toxicity induced by doxorubicin (adriamycin). |journal=Biochem. Pharmacol. |volume=52 |issue= 5 |pages= 713–22 |year= 1996 |pmid= 8765469 |doi=
*cite journal | author=Wiedemann FR, Vielhaber S, Schröder R, "et al." |title=Evaluation of methods for the determination of mitochondrial respiratory chain enzyme activities in human skeletal muscle samples. |journal=Anal. Biochem. |volume=279 |issue= 1 |pages= 55–60 |year= 2000 |pmid= 10683230 |doi= 10.1006/abio.1999.4434
*cite journal | author=Hüttemann M, Kadenbach B, Grossman LI |title=Mammalian subunit IV isoforms of cytochrome c oxidase. |journal=Gene |volume=267 |issue= 1 |pages= 111–23 |year= 2001 |pmid= 11311561 |doi=
*cite journal | author=Sampson V, Alleyne T |title=Cytochrome c/cytochrome c oxidase interaction. Direct structural evidence for conformational changes during enzyme turnover. |journal=Eur. J. Biochem. |volume=268 |issue= 24 |pages= 6534–44 |year= 2002 |pmid= 11737208 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Vizirianakis IS, Pappas IS, Tsiftsoglou AS |title=Differentiation-dependent repression of c-myc, B22, COX II and COX IV genes in murine erythroleukemia (MEL) cells. |journal=Biochem. Pharmacol. |volume=63 |issue= 5 |pages= 1009–17 |year= 2002 |pmid= 11911854 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fukuda R, Zhang H, Kim JW, "et al." |title=HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. |journal=Cell |volume=129 |issue= 1 |pages= 111–22 |year= 2007 |pmid= 17418790 |doi= 10.1016/j.cell.2007.01.047

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