PPFIA1

Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1, also known as PPFIA1, is a human gene.cite web | title = Entrez Gene: PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8500| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described.cite web | title = Entrez Gene: PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8500| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Serra-Pagès C, Kedersha NL, Fazikas L, "et al." |title=The LAR transmembrane protein tyrosine phosphatase and a coiled-coil LAR-interacting protein co-localize at focal adhesions. |journal=EMBO J. |volume=14 |issue= 12 |pages= 2827–38 |year= 1995 |pmid= 7796809 |doi=
*cite journal | author=Pulido R, Serra-Pagès C, Tang M, Streuli M |title=The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11686–90 |year= 1996 |pmid= 8524829 |doi=
*cite journal | author=Serra-Pagès C, Medley QG, Tang M, "et al." |title=Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15611–20 |year= 1998 |pmid= 9624153 |doi=
*cite journal | author=Wyszynski M, Kim E, Dunah AW, "et al." |title=Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. |journal=Neuron |volume=34 |issue= 1 |pages= 39–52 |year= 2002 |pmid= 11931740 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ko J, Kim S, Valtschanoff JG, "et al." |title=Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting. |journal=J. Neurosci. |volume=23 |issue= 5 |pages= 1667–77 |year= 2003 |pmid= 12629171 |doi=
*cite journal | author=Ko J, Na M, Kim S, "et al." |title=Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 42377–85 |year= 2004 |pmid= 12923177 |doi= 10.1074/jbc.M307561200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Jin J, Smith FD, Stark C, "et al." |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Serra-Pagès C, Streuli M, Medley QG |title=Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation. |journal=Biochemistry |volume=44 |issue= 48 |pages= 15715–24 |year= 2006 |pmid= 16313174 |doi= 10.1021/bi051434f
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Hoogenraad CC, Feliu-Mojer MI, Spangler SA, "et al." |title=Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development. |journal=Dev. Cell |volume=12 |issue= 4 |pages= 587–602 |year= 2007 |pmid= 17419996 |doi= 10.1016/j.devcel.2007.02.006

PBB_Controls
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