SPRED2

Sprouty-related, EVH1 domain containing 2, also known as SPRED2, is a human gene.cite web | title = Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200734| accessdate = ]

PBB_Summary
section_title =
summary_text = SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004). [supplied by OMIM] cite web | title = Entrez Gene: SPRED2 sprouty-related, EVH1 domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200734| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Wakioka T, Sasaki A, Kato R, "et al." |title=Spred is a Sprouty-related suppressor of Ras signalling. |journal=Nature |volume=412 |issue= 6847 |pages= 647–51 |year= 2001 |pmid= 11493923 |doi= 10.1038/35088082
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kato R, Nonami A, Taketomi T, "et al." |title=Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. |journal=Biochem. Biophys. Res. Commun. |volume=302 |issue= 4 |pages= 767–72 |year= 2003 |pmid= 12646235 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Nobuhisa I, Kato R, Inoue H, "et al." |title=Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation. |journal=J. Exp. Med. |volume=199 |issue= 5 |pages= 737–42 |year= 2004 |pmid= 14981116 |doi= 10.1084/jem.20030830
*cite journal | author=Miyoshi K, Wakioka T, Nishinakamura H, "et al." |title=The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization. |journal=Oncogene |volume=23 |issue= 33 |pages= 5567–76 |year= 2004 |pmid= 15184877 |doi= 10.1038/sj.onc.1207759
*cite journal | author=Zimmermann J, Jarchau T, Walter U, "et al." |title=1H, 13C and 15N resonance assignment of the human Spred2 EVH1 domain. |journal=J. Biomol. NMR |volume=29 |issue= 3 |pages= 435–6 |year= 2005 |pmid= 15213456 |doi= 10.1023/B:JNMR.0000032526.17586.8c
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Engelhardt CM, Bundschu K, Messerschmitt M, "et al." |title=Expression and subcellular localization of Spred proteins in mouse and human tissues. |journal=Histochem. Cell Biol. |volume=122 |issue= 6 |pages= 527–38 |year= 2005 |pmid= 15580519 |doi= 10.1007/s00418-004-0725-6
*cite journal | author=King JA, Straffon AF, D'Abaco GM, "et al." |title=Distinct requirements for the Sprouty domain for functional activity of Spred proteins. |journal=Biochem. J. |volume=388 |issue= Pt 2 |pages= 445–54 |year= 2005 |pmid= 15683364 |doi= 10.1042/BJ20041284
*cite journal | author=Bundschu K, Knobeloch KP, Ullrich M, "et al." |title=Gene disruption of Spred-2 causes dwarfism. |journal=J. Biol. Chem. |volume=280 |issue= 31 |pages= 28572–80 |year= 2005 |pmid= 15946934 |doi= 10.1074/jbc.M503640200
*cite journal | author=Yoshida T, Hisamoto T, Akiba J, "et al." |title=Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors. |journal=Oncogene |volume=25 |issue= 45 |pages= 6056–66 |year= 2006 |pmid= 16652141 |doi= 10.1038/sj.onc.1209635
*cite journal | author=Lock P, I ST, Straffon AF, "et al." |title=Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. |journal=Biochem. Biophys. Res. Commun. |volume=351 |issue= 4 |pages= 1018–23 |year= 2007 |pmid= 17094949 |doi= 10.1016/j.bbrc.2006.10.150

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