GMP phosphodiesterase, delta subunit

Pfam_box
Symbol = GMP_PDE_delta
Name = GMP-PDE, delta subunit

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width =250
caption =Membrane-bound ADP ribosylation factor-like protein 2 (ARL2 mouse, red), complex with phosphodiesterase delta (yellow) (PDB3|1ksg) Blue dots show hydrocarbon boundary of the lipid bilayer
Pfam= PF05351
InterPro= IPR008015
SMART=
Prosite =
SCOP = 1ksj
TCDB =
OPM family=
OPM protein= 1ksg
PDB=PDB3|1kshB:7-150 PDB3|1ksgB:7-150 PDB3|1ksjB:7-150

GMP-PDE delta subunit was originally identified as a fourth subunit of rod cell-specific cGMP phosphodiesterase (PDE) (EC number|3.1.4.35). The precise function of PDE delta subunit in the rod specific GMP-PDE complex is unclear. In addition, PDE delta subunit is not confined to photoreceptor cells but is widely distributed in different tissues. PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator of PDE-mediated transportcite journal |author=Wittinghofer A, Renault L, Hanzal-bayer M, Roversi P, Hillig RC |title=The complex of Arl2-GTP and PDE delta: from structure to function |journal=EMBO J. |volume=21 |issue=9 |pages=2095–2106 |year=2002 |pmid=11980706 |doi=10.1093/emboj/21.9.2095] .

Human proteins containing this domain

PDE6D; UNC119;

References