DPAGT1

DPAGT1
Dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
Identifiers
Symbols DPAGT1; ALG7; CDG-Ij; CDG1J; D11S366; DGPT; DPAGT; DPAGT2; G1PT; GPT; UAGT; UGAT
External IDs OMIM191350 MGI1196396 HomoloGene1058 GeneCards: DPAGT1 Gene
EC number 2.7.8.15
RNA expression pattern
PBB GE DPAGT1 209509 s at tn.png
PBB GE DPAGT1 212525 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1798 13478
Ensembl ENSG00000172269 ENSMUSG00000032123
UniProt Q9H3H5 Q9CPT1
RefSeq (mRNA) NM_001382 NM_007875.2
RefSeq (protein) NP_001373 NP_031901.2
Location (UCSC) Chr 11:
118.97 – 118.98 Mb
Chr 9:
44.13 – 44.14 Mb
PubMed search [1] [2]

UDP-N-acetylglucosamine—dolichyl-phosphate N-acetylglucosaminephosphotransferase is an enzyme that in humans is encoded by the DPAGT1 gene.[1][2]

The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

References

  1. ^ Smith MW, Clark SP, Hutchinson JS, Wei YH, Churukian AC, Daniels LB, Diggle KL, Gen MW, Romo AJ, Lin Y, et al. (Dec 1993). "A sequence-tagged site map of human chromosome 11". Genomics 17 (3): 699–725. doi:10.1006/geno.1993.1392. PMID 8244387. 
  2. ^ a b "Entrez Gene: DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1798. 

Further reading

External links




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