CDK5RAP3

CDK5 regulatory subunit associated protein 3, also known as CDK5RAP3, is a human gene.cite web | title = Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80279| accessdate = ]

PBB_Summary
section_title =
summary_text = Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation.cite web | title = Entrez Gene: CDK5RAP3 CDK5 regulatory subunit associated protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80279| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Ching YP, Qi Z, Wang JH |title=Cloning of three novel neuronal Cdk5 activator binding proteins. |journal=Gene |volume=242 |issue= 1-2 |pages= 285–94 |year= 2000 |pmid= 10721722 |doi=
*cite journal | author=Wang X, Ching YP, Lam WH, "et al." |title=Identification of a common protein association region in the neuronal Cdk5 activator. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31763–9 |year= 2000 |pmid= 10915792 |doi= 10.1074/jbc.M004358200
*cite journal | author=Ching YP, Pang AS, Lam WH, "et al." |title=Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15237–40 |year= 2002 |pmid= 11882646 |doi= 10.1074/jbc.C200032200
*cite journal | author=Chen J, Liu B, Liu Y, "et al." |title=A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 1 |pages= 161–6 |year= 2002 |pmid= 12054757 |doi= 10.1016/S0006-291X(02)00446-1
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Xie YH, He XH, Tang YT, "et al." |title=Cloning and characterization of human IC53-2, a novel CDK5 activator binding protein. |journal=Cell Res. |volume=13 |issue= 2 |pages= 83–91 |year= 2003 |pmid= 12737517 |doi= 10.1038/sj.cr.7290153
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Cen H, Zheng S, Fang YM, "et al." |title=Induction of HSF1 expression is associated with sporadic colorectal cancer. |journal=World J. Gastroenterol. |volume=10 |issue= 21 |pages= 3122–6 |year= 2004 |pmid= 15457556 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Jiang H, Luo S, Li H |title=Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint. |journal=J. Biol. Chem. |volume=280 |issue= 21 |pages= 20651–9 |year= 2005 |pmid= 15790566 |doi= 10.1074/jbc.M413431200
*cite journal | author=Yin X, Warner DR, Roberts EA, "et al." |title=Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53. |journal=Int. J. Mol. Med. |volume=16 |issue= 2 |pages= 251–6 |year= 2005 |pmid= 16012757 |doi=
*cite journal | author=Wang J, He X, Luo Y, Yarbrough WG |title=A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2. |journal=Biochem. J. |volume=393 |issue= Pt 2 |pages= 489–501 |year= 2006 |pmid= 16173922 |doi= 10.1042/BJ20050960
*cite journal | author=Kim E, Chen F, Wang CC, Harrison LE |title=CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation. |journal=Int. J. Oncol. |volume=28 |issue= 1 |pages= 191–4 |year= 2006 |pmid= 16327995 |doi=
*cite journal | author=Camargo LM, Collura V, Rain JC, "et al." |title=Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. |journal=Mol. Psychiatry |volume=12 |issue= 1 |pages= 74–86 |year= 2007 |pmid= 17043677 |doi= 10.1038/sj.mp.4001880
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Stav D, Bar I, Sandbank J |title=Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma. |journal=Int. J. Biol. Markers |volume=22 |issue= 2 |pages= 108–13 |year= 2007 |pmid= 17549666 |doi=
*cite journal | author=Wang J, An H, Mayo MW, "et al." |title=LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB. |journal=Cancer Cell |volume=12 |issue= 3 |pages= 239–51 |year= 2007 |pmid= 17785205 |doi= 10.1016/j.ccr.2007.07.002

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