NUF2

NUF2
NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)

Rendering based on PDB 2VE7.
Identifiers
Symbols NUF2; CDCA1; CT106; NUF2R
External IDs OMIM611772 MGI1914227 HomoloGene40205 GeneCards: NUF2 Gene
Orthologs
Species Human Mouse
Entrez 83540 66977
Ensembl ENSG00000143228 ENSMUSG00000026683
UniProt Q9BZD4 Q99P69
RefSeq (mRNA) NM_031423.3 NM_023284.3
RefSeq (protein) NP_113611.2 NP_075773.2
Location (UCSC) Chr 1:
163.24 – 163.33 Mb
Chr 1:
171.43 – 171.46 Mb
PubMed search [1] [2]

Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.[1][2][3]

This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.[3]

References

  1. ^ Wigge PA, Kilmartin JV (Mar 2001). "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation". J Cell Biol 152 (2): 349–60. doi:10.1083/jcb.152.2.349. PMC 2199619. PMID 11266451. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2199619. 
  2. ^ Nabetani A, Koujin T, Tsutsumi C, Haraguchi T, Hiraoka Y (Oct 2001). "A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint". Chromosoma 110 (5): 322–34. doi:10.1007/s004120100153. PMID 11685532. 
  3. ^ a b "Entrez Gene: NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83540. 

Further reading


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • NDC80 — homolog, kinetochore complex component (S. cerevisiae) PDB rendering based on 2igp …   Wikipedia

  • Cinetocoro — Imagen de una célula humana en mitosis, en la que los microtúbulos se muestran en verde (formando el huso mitótico), los cromosomas en azul en el ecuador del huso y los cinetocoros en rojo. El cinetocoro es una estructura proteica situada sobre… …   Wikipedia Español

  • CENPH — Centromere protein H, also known as CENPH, is a human gene.cite web | title = Entrez Gene: CENPH centromere protein H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=64946| accessdate = ] PBB Summary… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”