PACS1

PACS1
Phosphofurin acidic cluster sorting protein 1
Identifiers
Symbols PACS1; FLJ10209; KIAA1175
External IDs OMIM607492 MGI1277113 HomoloGene9970 GeneCards: PACS1 Gene
RNA expression pattern
PBB GE PACS1 gnf1h02048 at tn.png
PBB GE PACS1 gnf1h05641 at tn.png
PBB GE PACS1 gnf1h02050 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 55690 107975
Ensembl ENSG00000175115 ENSMUSG00000024855
UniProt Q6VY07 Q3TAB8
RefSeq (mRNA) NM_018026 NM_153129.2
RefSeq (protein) NP_060496 NP_694769.2
Location (UCSC) Chr 11:
65.84 – 66.01 Mb
Chr 19:
5.13 – 5.27 Mb
PubMed search [1] [2]

Phosphofurin acidic cluster sorting protein 1 also known as PACS-1 is a protein that in humans is encoded by the PACS1 gene.[1][2][3]

Contents

Function

The PACS-1 protein has a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.[3]

Interactions

PACS1 has been shown to interact with Furin.[4]

References

  1. ^ Stove V, Naessens E, Stove C, Swigut T, Plum J, Verhasselt B (Oct 2003). "Signaling but not trafficking function of HIV-1 protein Nef is essential for Nef-induced defects in human intrathymic T-cell development". Blood 102 (8): 2925–32. doi:10.1182/blood-2003-03-0833. PMID 12855553. 
  2. ^ Hinners I, Wendler F, Fei H, Thomas L, Thomas G, Tooze SA (Dec 2003). "AP-1 recruitment to VAMP4 is modulated by phosphorylation-dependent binding of PACS-1". EMBO Rep 4 (12): 1182–9. doi:10.1038/sj.embor.7400018. PMC 1326413. PMID 14608369. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1326413. 
  3. ^ a b "Entrez Gene: PACS1 phosphofurin acidic cluster sorting protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55690. 
  4. ^ Wan, L; Molloy S S, Thomas L, Liu G, Xiang Y, Rybak S L, Thomas G (Jul. 1998). "PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization". Cell (UNITED STATES) 94 (2): 205–16. doi:10.1016/S0092-8674(00)81420-8. ISSN 0092-8674. PMID 9695949. 


Further reading


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Look at other dictionaries:

  • Furin — FUR redirects here. For other uses, see Fur (disambiguation). Furin (paired basic amino acid cleaving enzyme) PDB rendering based on 1p8j …   Wikipedia

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