FGF4

Fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene), also known as FGF4, is a human gene.cite web | title = Entrez Gene: FGF4 fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2249| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.cite web | title = Entrez Gene: FGF4 fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2249| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Powers CJ, McLeskey SW, Wellstein A |title=Fibroblast growth factors, their receptors and signaling. |journal=Endocr. Relat. Cancer |volume=7 |issue= 3 |pages= 165–97 |year= 2000 |pmid= 11021964 |doi=
*cite journal | author=Galland F, Stefanova M, Lafage M, Birnbaum D |title=Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23. |journal=Cytogenet. Cell Genet. |volume=60 |issue= 2 |pages= 114–6 |year= 1992 |pmid= 1611909 |doi=
*cite journal | author=Taira M, Yoshida T, Miyagawa K, "et al." |title=cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 9 |pages= 2980–4 |year= 1987 |pmid= 2953031 |doi=
*cite journal | author=Delli Bovi P, Curatola AM, Kern FG, "et al." |title=An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family. |journal=Cell |volume=50 |issue= 5 |pages= 729–37 |year= 1987 |pmid= 2957062 |doi=
*cite journal | author=Yoshida T, Miyagawa K, Odagiri H, "et al." |title=Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 20 |pages= 7305–9 |year= 1987 |pmid= 2959959 |doi=
*cite journal | author=Wada A, Sakamoto H, Katoh O, "et al." |title=Two homologous oncogenes, HST1 and INT2, are closely located in human genome. |journal=Biochem. Biophys. Res. Commun. |volume=157 |issue= 2 |pages= 828–35 |year= 1989 |pmid= 2974287 |doi=
*cite journal | author=Huebner K, Ferrari AC, Delli Bovi P, "et al." |title=The FGF-related oncogene, K-FGF, maps to human chromosome region 11q13, possibly near int-2. |journal=Oncogene Res. |volume=3 |issue= 3 |pages= 263–70 |year= 1989 |pmid= 3060803 |doi=
*cite journal | author=Adelaide J, Mattei MG, Marics I, "et al." |title=Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in a human melanoma. |journal=Oncogene |volume=2 |issue= 4 |pages= 413–6 |year= 1988 |pmid= 3283658 |doi=
*cite journal | author=Ornitz DM, Xu J, Colvin JS, "et al." |title=Receptor specificity of the fibroblast growth factor family. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15292–7 |year= 1996 |pmid= 8663044 |doi=
*cite journal | author=Helland R, Berglund GI, Otlewski J, "et al." |title=High-resolution structures of three new trypsin-squash-inhibitor complexes: a detailed comparison with other trypsins and their complexes. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=55 |issue= Pt 1 |pages= 139–48 |year= 1999 |pmid= 10089404 |doi= 10.1107/S090744499801052X
*cite journal | author=Bellosta P, Iwahori A, Plotnikov AN, "et al." |title=Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis. |journal=Mol. Cell. Biol. |volume=21 |issue= 17 |pages= 5946–57 |year= 2001 |pmid= 11486033 |doi=
*cite journal | author=Britto JA, Evans RD, Hayward RD, Jones BM |title=From genotype to phenotype: the differential expression of FGF, FGFR, and TGFbeta genes characterizes human cranioskeletal development and reflects clinical presentation in FGFR syndromes. |journal=Plast. Reconstr. Surg. |volume=108 |issue= 7 |pages= 2026–39; discussion 2040–6 |year= 2002 |pmid= 11743396 |doi=
*cite journal | author=Yamamoto H, Ochiya T, Tamamushi S, "et al." |title=HST-1/FGF-4 gene activation induces spermatogenesis and prevents adriamycin-induced testicular toxicity. |journal=Oncogene |volume=21 |issue= 6 |pages= 899–908 |year= 2002 |pmid= 11840335 |doi= 10.1038/sj.onc.1205135
*cite journal | author=Sieuwerts AM, Martens JW, Dorssers LC, "et al." |title=Differential effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems by human breast fibroblasts. |journal=Thromb. Haemost. |volume=87 |issue= 4 |pages= 674–83 |year= 2003 |pmid= 12008951 |doi=
*cite journal | author=Koh KR, Ohta K, Nakamae H, "et al." |title=Differential effects of fibroblast growth factor-4, epidermal growth factor and transforming growth factor-beta1 on functional development of stromal layers in acute myeloid leukemia. |journal=Leuk. Res. |volume=26 |issue= 10 |pages= 933–8 |year= 2002 |pmid= 12163055 |doi=
*cite journal | author=Lopez-Sanchez C, Climent V, Schoenwolf GC, "et al." |title=Induction of cardiogenesis by Hensen's node and fibroblast growth factors. |journal=Cell Tissue Res. |volume=309 |issue= 2 |pages= 237–49 |year= 2003 |pmid= 12172783 |doi= 10.1007/s00441-002-0567-2
*cite journal | author=Wang P, Branch DR, Bali M, "et al." |title=The POU homeodomain protein OCT3 as a potential transcriptional activator for fibroblast growth factor-4 (FGF-4) in human breast cancer cells. |journal=Biochem. J. |volume=375 |issue= Pt 1 |pages= 199–205 |year= 2003 |pmid= 12841847 |doi= 10.1042/BJ20030579
*cite journal | author=Reményi A, Lins K, Nissen LJ, "et al." |title=Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. |journal=Genes Dev. |volume=17 |issue= 16 |pages= 2048–59 |year= 2003 |pmid= 12923055 |doi= 10.1101/gad.269303
*cite journal | author=Hirai K, Sasaki H, Yamamoto H, "et al." |title=HST-1/FGF-4 protects male germ cells from apoptosis under heat-stress condition. |journal=Exp. Cell Res. |volume=294 |issue= 1 |pages= 77–85 |year= 2004 |pmid= 14980503 |doi= 10.1016/j.yexcr.2003.11.012

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes