RNF7

Ring finger protein 7, also known as RNF7, is a human gene.cite web | title = Entrez Gene: RNF7 ring finger protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9616| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.cite web | title = Entrez Gene: RNF7 ring finger protein 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9616| accessdate = ]

ee also

* RING finger domain

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Duan H, Wang Y, Aviram M, "et al." |title=SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents. |journal=Mol. Cell. Biol. |volume=19 |issue= 4 |pages= 3145–55 |year= 1999 |pmid= 10082581 |doi=
*cite journal | author=Tan P, Fuchs SY, Chen A, "et al." |title=Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 527–33 |year= 1999 |pmid= 10230406 |doi=
*cite journal | author=Ohta T, Michel JJ, Schottelius AJ, Xiong Y |title=ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. |journal=Mol. Cell |volume=3 |issue= 4 |pages= 535–41 |year= 1999 |pmid= 10230407 |doi=
*cite journal | author=Swaroop M, Bian J, Aviram M, "et al." |title=Expression, purification, and biochemical characterization of SAG, a ring finger redox-sensitive protein. |journal=Free Radic. Biol. Med. |volume=27 |issue= 1-2 |pages= 193–202 |year= 1999 |pmid= 10443936 |doi=
*cite journal | author=Sun Y |title=Alterations of SAG mRNA in human cancer cell lines: requirement for the RING finger domain for apoptosis protection. |journal=Carcinogenesis |volume=20 |issue= 10 |pages= 1899–903 |year= 1999 |pmid= 10506102 |doi=
*cite journal | author=Son MY, Park JW, Kim YS, "et al." |title=Protein kinase CKII interacts with and phosphorylates the SAG protein containing ring-H2 finger motif. |journal=Biochem. Biophys. Res. Commun. |volume=263 |issue= 3 |pages= 743–8 |year= 1999 |pmid= 10512750 |doi= 10.1006/bbrc.1999.1460
*cite journal | author=Chen A, Wu K, Fuchs SY, "et al." |title=The conserved RING-H2 finger of ROC1 is required for ubiquitin ligation. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15432–9 |year= 2000 |pmid= 10748083 |doi= 10.1074/jbc.M907300199
*cite journal | author=Swaroop M, Wang Y, Miller P, "et al." |title=Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation. |journal=Oncogene |volume=19 |issue= 24 |pages= 2855–66 |year= 2000 |pmid= 10851089 |doi= 10.1038/sj.onc.1203635
*cite journal | author=Furukawa M, Zhang Y, McCarville J, "et al." |title=The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 8185–97 |year= 2000 |pmid= 11027288 |doi=
*cite journal | author=Duan H, Tsvetkov LM, Liu Y, "et al." |title=Promotion of S-phase entry and cell growth under serum starvation by SAG/ROC2/Rbx2/Hrt2, an E3 ubiquitin ligase component: association with inhibition of p27 accumulation. |journal=Mol. Carcinog. |volume=30 |issue= 1 |pages= 37–46 |year= 2001 |pmid= 11255262 |doi=
*cite journal | author=Swaroop M, Gosink M, Sun Y |title=SAG/ROC2/Rbx2/Hrt2, a component of SCF E3 ubiquitin ligase: genomic structure, a splicing variant, and two family pseudogenes. |journal=DNA Cell Biol. |volume=20 |issue= 7 |pages= 425–34 |year= 2001 |pmid= 11506706 |doi= 10.1089/104454901750361488
*cite journal | author=Ahn BH, Kim TH, Bae YS |title=Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins. |journal=Mol. Cells |volume=12 |issue= 2 |pages= 158–63 |year= 2002 |pmid= 11710515 |doi=
*cite journal | author=Furukawa M, Ohta T, Xiong Y |title=Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15758–65 |year= 2002 |pmid= 11861641 |doi= 10.1074/jbc.M108565200
*cite journal | author=Kim SY, Bae YS, Park JW |title=Thiol-linked peroxidase activity of human sensitive to apoptosis gene (SAG) protein. |journal=Free Radic. Res. |volume=36 |issue= 1 |pages= 73–8 |year= 2002 |pmid= 11999705 |doi=
*cite journal | author=Kim YS, Ha KS, Kim YH, Bae YS |title=The Ring-H2 finger motif of CKBBP1/SAG is necessary for interaction with protein kinase CKII and optimal cell proliferation. |journal=J. Biochem. Mol. Biol. |volume=35 |issue= 6 |pages= 629–36 |year= 2003 |pmid= 12470599 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kim SY, Lee JH, Yang ES, "et al." |title=Human sensitive to apoptosis gene protein inhibits peroxynitrite-induced DNA damage. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 3 |pages= 671–4 |year= 2003 |pmid= 12565832 |doi=
*cite journal | author=Kim YS, Lee JY, Son MY, "et al." |title=Phosphorylation of threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by protein kinase CKII promotes the degradation of IkappaBalpha and p27Kip1. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28462–9 |year= 2003 |pmid= 12748192 |doi= 10.1074/jbc.M302584200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

External links

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