ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1, also known as ARHGEF1, is a human gene.cite web | title = Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9138| accessdate = ]

PBB_Summary
section_title =
summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.cite web | title = Entrez Gene: ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9138| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Fukuhara S, Chikumi H, Gutkind JS |title=RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho? |journal=Oncogene |volume=20 |issue= 13 |pages= 1661–8 |year= 2001 |pmid= 11313914 |doi= 10.1038/sj.onc.1204182
*cite journal | author=Hart MJ, Sharma S, elMasry N, "et al." |title=Identification of a novel guanine nucleotide exchange factor for the Rho GTPase. |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25452–8 |year= 1996 |pmid= 8810315 |doi=
*cite journal | author=Aasheim HC, Pedeutour F, Smeland EB |title=Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues. |journal=Oncogene |volume=14 |issue= 14 |pages= 1747–52 |year= 1997 |pmid= 9135076 |doi= 10.1038/sj.onc.1200994
*cite journal | author=Kozasa T, Jiang X, Hart MJ, "et al." |title=p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. |journal=Science |volume=280 |issue= 5372 |pages= 2109–11 |year= 1998 |pmid= 9641915 |doi=
*cite journal | author=Hart MJ, Jiang X, Kozasa T, "et al." |title=Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. |journal=Science |volume=280 |issue= 5372 |pages= 2112–4 |year= 1998 |pmid= 9641916 |doi=
*cite journal | author=Zhang H, Wang L, Kao S, "et al." |title=Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF. |journal=Curr. Biol. |volume=9 |issue= 21 |pages= 1271–4 |year= 1999 |pmid= 10556093 |doi=
*cite journal | author=Kim ST, Lim DS, Canman CE, Kastan MB |title=Substrate specificities and identification of putative substrates of ATM kinase family members. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37538–43 |year= 2000 |pmid= 10608806 |doi=
*cite journal | author=Bhattacharyya R, Wedegaertner PB |title=Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 14992–9 |year= 2000 |pmid= 10747909 |doi= 10.1074/jbc.M000415200
*cite journal | author=Kozasa T |title=Regulation of G protein-mediated signal transduction by RGS proteins. |journal=Life Sci. |volume=68 |issue= 19-20 |pages= 2309–17 |year= 2001 |pmid= 11358341 |doi=
*cite journal | author=Wells CD, Gutowski S, Bollag G, Sternweis PC |title=Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28897–905 |year= 2001 |pmid= 11384980 |doi= 10.1074/jbc.M102913200
*cite journal | author=Chen Z, Wells CD, Sternweis PC, Sprang SR |title=Structure of the rgRGS domain of p115RhoGEF. |journal=Nat. Struct. Biol. |volume=8 |issue= 9 |pages= 805–9 |year= 2001 |pmid= 11524686 |doi= 10.1038/nsb0901-805
*cite journal | author=Park B, Nguyen NT, Dutt P, "et al." |title=Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45361–70 |year= 2003 |pmid= 12270917 |doi= 10.1074/jbc.M202447200
*cite journal | author=Driessens MH, Olivo C, Nagata K, "et al." |title=B plexins activate Rho through PDZ-RhoGEF. |journal=FEBS Lett. |volume=529 |issue= 2-3 |pages= 168–72 |year= 2002 |pmid= 12372594 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chen Z, Singer WD, Wells CD, "et al." |title=Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF. |journal=J. Biol. Chem. |volume=278 |issue= 11 |pages= 9912–9 |year= 2003 |pmid= 12525488 |doi= 10.1074/jbc.M212695200
*cite journal | author=Bhattacharyya R, Wedegaertner PB |title=Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF. |journal=Biochem. J. |volume=371 |issue= Pt 3 |pages= 709–20 |year= 2003 |pmid= 12534370 |doi= 10.1042/BJ20021897
*cite journal | author=Bhattacharyya R, Wedegaertner PB |title=Mutation of an N-terminal acidic-rich region of p115-RhoGEF dissociates alpha13 binding and alpha13-promoted plasma membrane recruitment. |journal=FEBS Lett. |volume=540 |issue= 1-3 |pages= 211–6 |year= 2003 |pmid= 12681510 |doi=
*cite journal | author=Bourguignon LY, Singleton PA, Zhu H, Diedrich F |title=Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 29420–34 |year= 2003 |pmid= 12748184 |doi= 10.1074/jbc.M301885200
*cite journal | author=Holinstat M, Mehta D, Kozasa T, "et al." |title=Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. |journal=J. Biol. Chem. |volume=278 |issue= 31 |pages= 28793–8 |year= 2003 |pmid= 12754211 |doi= 10.1074/jbc.M303900200

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