NDRG2

NDRG2
NDRG family member 2
Identifiers
Symbols NDRG2; DKFZp781G1938; FLJ25522; KIAA1248; SYLD
External IDs OMIM605272 MGI1352498 HomoloGene22785 GeneCards: NDRG2 Gene
RNA expression pattern
PBB GE NDRG2 214279 s at tn.png
PBB GE NDRG2 206453 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57447 29811
Ensembl ENSG00000165795 ENSMUSG00000004558
UniProt Q9UN36 Q8CGR9
RefSeq (mRNA) NM_016250.2 NM_013864
RefSeq (protein) NP_057334.1 NP_038892
Location (UCSC) Chr 14:
21.48 – 21.54 Mb
Chr 14:
52.52 – 52.53 Mb
PubMed search [1] [2]

Protein NDRG2 is a protein that in humans is encoded by the NDRG2 gene (NMYC downstrean-regulated gene 2).[1][2]

Function

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[2]

References

  1. ^ Kalaydjieva L, Gresham D, Gooding R, Heather L, Baas F, de Jonge R, Blechschmidt K, Angelicheva D, Chandler D, Worsley P, Rosenthal A, King RH, Thomas PK (Aug 2000). "N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom". Am J Hum Genet 67 (1): 47–58. doi:10.1086/302978. PMC 1287101. PMID 10831399. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1287101. 
  2. ^ a b "Entrez Gene: NDRG2 NDRG family member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57447. 

Further reading


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