PSCD1

Pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1), also known as PSCD1, is a human gene.cite web | title = Entrez Gene: PSCD1 pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9267| accessdate = ]

PBB_Summary
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summary_text = Pleckstrin homology, Sec7 and coiled/coil domains 1 (PSCD1) is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The PSCD1 is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. PSCD1 protein is 83% homologous to PSCD2.cite web | title = Entrez Gene: PSCD1 pleckstrin homology, Sec7 and coiled-coil domains 1(cytohesin 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9267| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Liu L, Pohajdak B |title=Cloning and sequencing of a human cDNA from cytolytic NK/T cells with homology to yeast SEC7. |journal=Biochim. Biophys. Acta |volume=1132 |issue= 1 |pages= 75–8 |year= 1992 |pmid= 1511013 |doi=
*cite journal | author=Dixon B, Mansour M, Pohajdak B |title=Assignment of human B2-1 gene (D17S811E) to chromosome 17qter by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=63 |issue= 1 |pages= 42–4 |year= 1993 |pmid= 8449036 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Kolanus W, Nagel W, Schiller B, "et al." |title=Alpha L beta 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. |journal=Cell |volume=86 |issue= 2 |pages= 233–42 |year= 1996 |pmid= 8706128 |doi=
*cite journal | author=Meacci E, Tsai SC, Adamik R, "et al." |title=Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 5 |pages= 1745–8 |year= 1997 |pmid= 9050849 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Nagel W, Zeitlmann L, Schilcher P, "et al." |title=Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1. |journal=J. Biol. Chem. |volume=273 |issue= 24 |pages= 14853–61 |year= 1998 |pmid= 9614087 |doi=
*cite journal | author=Betz SF, Schnuchel A, Wang H, "et al." |title=Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 14 |pages= 7909–14 |year= 1998 |pmid= 9653114 |doi=
*cite journal | author=Nagel W, Schilcher P, Zeitlmann L, Kolanus W |title=The PH domain and the polybasic c domain of cytohesin-1 cooperate specifically in plasma membrane association and cellular function. |journal=Mol. Biol. Cell |volume=9 |issue= 8 |pages= 1981–94 |year= 1998 |pmid= 9693361 |doi=
*cite journal | author=Pacheco-Rodriguez G, Meacci E, Vitale N, "et al." |title=Guanine nucleotide exchange on ADP-ribosylation factors catalyzed by cytohesin-1 and its Sec7 domain. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26543–8 |year= 1998 |pmid= 9756891 |doi=
*cite journal | author=Rietzler M, Bittner M, Kolanus W, "et al." |title=The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27459–66 |year= 1998 |pmid= 9765275 |doi=
*cite journal | author=Schürmann A, Schmidt M, Asmus M, "et al." |title=The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D. |journal=J. Biol. Chem. |volume=274 |issue= 14 |pages= 9744–51 |year= 1999 |pmid= 10092663 |doi=
*cite journal | author=Pacheco-Rodriguez G, Patton WA, Adamik R, "et al." |title=Structural elements of ADP-ribosylation factor 1 required for functional interaction with cytohesin-1. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12438–44 |year= 1999 |pmid= 10212218 |doi=
*cite journal | author=Venkateswarlu K, Gunn-Moore F, Tavaré JM, Cullen PJ |title=EGF-and NGF-stimulated translocation of cytohesin-1 to the plasma membrane of PC12 cells requires PI 3-kinase activation and a functional cytohesin-1 PH domain. |journal=J. Cell. Sci. |volume=112 ( Pt 12) |issue= |pages= 1957–65 |year= 1999 |pmid= 10341214 |doi=
*cite journal | author=Ogasawara M, Kim SC, Adamik R, "et al." |title=Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3221–30 |year= 2000 |pmid= 10652308 |doi=
*cite journal | author=Vitale N, Pacheco-Rodriguez G, Ferrans VJ, "et al." |title=Specific functional interaction of human cytohesin-1 and ADP-ribosylation factor domain protein (ARD1). |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21331–9 |year= 2000 |pmid= 10748148 |doi= 10.1074/jbc.M909642199
*cite journal | author=Lee SY, Mansour M, Pohajdak B |title=B2-1, a Sec7- and pleckstrin homology domain-containing protein, localizes to the Golgi complex. |journal=Exp. Cell Res. |volume=256 |issue= 2 |pages= 515–21 |year= 2000 |pmid= 10772823 |doi= 10.1006/excr.2000.4845
*cite journal | author=Geiger C, Nagel W, Boehm T, "et al." |title=Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1. |journal=EMBO J. |volume=19 |issue= 11 |pages= 2525–36 |year= 2000 |pmid= 10835351 |doi= 10.1093/emboj/19.11.2525
*cite journal | author=Dierks H, Kolanus J, Kolanus W |title=Actin cytoskeletal association of cytohesin-1 is regulated by specific phosphorylation of its carboxyl-terminal polybasic domain. |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 37472–81 |year= 2001 |pmid= 11438522 |doi= 10.1074/jbc.M101502200
*cite journal | author=Tang P, Cheng TP, Agnello D, "et al." |title=Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 2625–9 |year= 2002 |pmid= 11867758 |doi= 10.1073/pnas.052712999

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