ANXA4

Annexin A4, also known as ANXA4, is a human gene.cite web | title = Entrez Gene: ANXA4 annexin A4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=307| accessdate = ]

PBB_Summary
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summary_text = Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.cite web | title = Entrez Gene: ANXA4 annexin A4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=307| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tait JF, Smith C, Frankenberry DA, "et al." |title=Chromosomal mapping of the human annexin IV (ANX4) gene. |journal=Genomics |volume=12 |issue= 2 |pages= 313–8 |year= 1992 |pmid= 1346776 |doi=
*cite journal | author=Römisch J, Heimburger N |title=Purification and characterization of six annexins from human placenta. |journal=Biol. Chem. Hoppe-Seyler |volume=371 |issue= 5 |pages= 383–8 |year= 1990 |pmid= 2143074 |doi=
*cite journal | author=Römisch J, Grote M, Weithmann KU, "et al." |title=Annexin proteins PP4 and PP4-X. Comparative characterization of biological activities of placental and recombinant proteins. |journal=Biochem. J. |volume=272 |issue= 1 |pages= 223–9 |year= 1991 |pmid= 2148260 |doi=
*cite journal | author=Freemont PS, Driessen HP, Verbi W, Crumpton MJ |title=Crystallization and preliminary X-ray crystallographic studies of human placental annexin IV. |journal=J. Mol. Biol. |volume=216 |issue= 2 |pages= 219–21 |year= 1991 |pmid= 2254922 |doi=
*cite journal | author=Hauptmann R, Maurer-Fogy I, Krystek E, "et al." |title=Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha. |journal=Eur. J. Biochem. |volume=185 |issue= 1 |pages= 63–71 |year= 1989 |pmid= 2530088 |doi=
*cite journal | author=Grundmann U, Amann E, Abel KJ, Küpper HA |title=Isolation and expression of cDNA coding for a new member of the phospholipase A2 inhibitor family. |journal=Behring Inst. Mitt. |volume= |issue= 82 |pages= 59–67 |year= 1988 |pmid= 2970257 |doi=
*cite journal | author=Ahn NG, Teller DC, Bienkowski MJ, "et al." |title=Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor. |journal=J. Biol. Chem. |volume=263 |issue= 35 |pages= 18657–63 |year= 1989 |pmid= 2974032 |doi=
*cite journal | author=Tait JF, Sakata M, McMullen BA, "et al." |title=Placental anticoagulant proteins: isolation and comparative characterization four members of the lipocortin family. |journal=Biochemistry |volume=27 |issue= 17 |pages= 6268–76 |year= 1989 |pmid= 2975506 |doi=
*cite journal | author=Sjölin C, Stendahl O, Dahlgren C |title=Calcium-induced translocation of annexins to subcellular organelles of human neutrophils. |journal=Biochem. J. |volume=300 ( Pt 2) |issue= |pages= 325–30 |year= 1994 |pmid= 8002935 |doi=
*cite journal | author=Kojima K, Yamamoto K, Irimura T, "et al." |title=Characterization of carbohydrate-binding protein p33/41: relation with annexin IV, molecular basis of the doublet forms (p33 and p41), and modulation of the carbohydrate binding activity by phospholipids. |journal=J. Biol. Chem. |volume=271 |issue= 13 |pages= 7679–85 |year= 1996 |pmid= 8631806 |doi=
*cite journal | author=Davis AJ, Butt JT, Walker JH, "et al." |title=The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24333–6 |year= 1996 |pmid= 8798684 |doi=
*cite journal | author=Satoh A, Takayama E, Kojima K, "et al." |title=Expression of carbohydrate-binding protein p33/41 in human tumor cell lines. |journal=J. Biochem. |volume=119 |issue= 2 |pages= 346–53 |year= 1997 |pmid= 8882729 |doi=
*cite journal | author=Satoh A, Takayama E, Kojima K, "et al." |title=Characterization of human p33/41 (annexin IV), a Ca2+ dependent carbohydrate-binding protein with monoclonal anti-annexin IV antibodies, AS11 and AS17. |journal=Biol. Pharm. Bull. |volume=20 |issue= 3 |pages= 224–9 |year= 1997 |pmid= 9084877 |doi=
*cite journal | author=Dreier R, Schmid KW, Gerke V, Riehemann K |title=Differential expression of annexins I, II and IV in human tissues: an immunohistochemical study. |journal=Histochem. Cell Biol. |volume=110 |issue= 2 |pages= 137–48 |year= 1998 |pmid= 9720986 |doi=
*cite journal | author=Chow A, Davis AJ, Gawler DJ |title=Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain. |journal=FEBS Lett. |volume=469 |issue= 1 |pages= 88–92 |year= 2000 |pmid= 10708762 |doi=
*cite journal | author=Han EK, Tahir SK, Cherian SP, "et al." |title=Modulation of paclitaxel resistance by annexin IV in human cancer cell lines. |journal=Br. J. Cancer |volume=83 |issue= 1 |pages= 83–8 |year= 2000 |pmid= 10883672 |doi= 10.1054/bjoc.2000.1311
*cite journal | author=Radau B, Otto A, Müller EC, Westermann P |title=Protein kinase C alpha-dependent phosphorylation of Golgi proteins. |journal=Electrophoresis |volume=21 |issue= 13 |pages= 2684–7 |year= 2001 |pmid= 10949146 |doi= 10.1002/1522-2683(20000701)21:13<2684::AID-ELPS2684>3.0.CO;2-G |doilabel=10.1002/1522-2683(20000701)21:132684::AID-ELPS26843.0.CO;2-G
*cite journal | author=Gerner C, Frohwein U, Gotzmann J, "et al." |title=The Fas-induced apoptosis analyzed by high throughput proteome analysis. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39018–26 |year= 2001 |pmid= 10978337 |doi= 10.1074/jbc.M006495200
*cite journal | author=Tsujii-Hayashi Y, Kitahara M, Yamagaki T, "et al." |title=A potential endogenous ligand of annexin IV in the exocrine pancreas. Carbohydrate structure of GP-2, a glycosylphosphatidylinositol-anchored glycoprotein of zymogen granule membranes. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47493–9 |year= 2003 |pmid= 12324456 |doi= 10.1074/jbc.M206572200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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