GCLC

Glutamate-cysteine ligase, catalytic subunit, also known as GCLC, is a human gene.cite web | title = Entrez Gene: GCLC glutamate-cysteine ligase, catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2729| accessdate = ]

PBB_Summary
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summary_text = Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.cite web | title = Entrez Gene: GCLC glutamate-cysteine ligase, catalytic subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2729| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Dickinson DA, Levonen AL, Moellering DR, "et al." |title=Human glutamate cysteine ligase gene regulation through the electrophile response element. |journal=Free Radic. Biol. Med. |volume=37 |issue= 8 |pages= 1152–9 |year= 2005 |pmid= 15451055 |doi= 10.1016/j.freeradbiomed.2004.06.011
*cite journal | author=Lebo RV, Kredich NM |title=Inactivation of human gamma-glutamylcysteine synthetase by cystamine. Demonstration and quantification of enzyme-ligand complexes. |journal=J. Biol. Chem. |volume=253 |issue= 8 |pages= 2615–23 |year= 1978 |pmid= 24639 |doi=
*cite journal | author=Gipp JJ, Chang C, Mulcahy RT |title=Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetase. |journal=Biochem. Biophys. Res. Commun. |volume=185 |issue= 1 |pages= 29–35 |year= 1992 |pmid= 1350904 |doi=
*cite journal | author=Beutler E, Moroose R, Kramer L, "et al." |title=Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia. |journal=Blood |volume=75 |issue= 1 |pages= 271–3 |year= 1990 |pmid= 2294991 |doi=
*cite journal | author=Konrad PN, Richards F, Valentine WN, Paglia DE |title=-Glutamyl-cysteine synthetase deficiency. A cause of hereditary hemolytic anemia. |journal=N. Engl. J. Med. |volume=286 |issue= 11 |pages= 557–61 |year= 1972 |pmid= 5058793 |doi=
*cite journal | author=Mulcahy RT, Gipp JJ |title=Identification of a putative antioxidant response element in the 5'-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene. |journal=Biochem. Biophys. Res. Commun. |volume=209 |issue= 1 |pages= 227–33 |year= 1995 |pmid= 7726839 |doi= 10.1006/bbrc.1995.1493
*cite journal | author=Sierra-Rivera E, Summar ML, Dasouki M, "et al." |title=Assignment of the gene (GLCLC) that encodes the heavy subunit of gamma-glutamylcysteine synthetase to human chromosome 6. |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3-4 |pages= 278–9 |year= 1995 |pmid= 7789189 |doi=
*cite journal | author=Kondo T, Yoshida K, Urata Y, "et al." |title=gamma-Glutamylcysteine synthetase and active transport of glutathione S-conjugate are responsive to heat shock in K562 erythroid cells. |journal=J. Biol. Chem. |volume=268 |issue= 27 |pages= 20366–72 |year= 1993 |pmid= 8104187 |doi=
*cite journal | author=Tsuchiya K, Mulcahy RT, Reid LL, "et al." |title=Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. |journal=Genomics |volume=30 |issue= 3 |pages= 630–2 |year= 1997 |pmid= 8825659 |doi= 10.1006/geno.1995.1293
*cite journal | author=Walsh AC, Li W, Rosen DR, Lawrence DA |title=Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of gamma-glutamyl-cysteine synthetase, to chromosome band 6p12 and characterization of a polymorphic trinucleotide repeat within its 5' untranslated region. |journal=Cytogenet. Cell Genet. |volume=75 |issue= 1 |pages= 14–6 |year= 1997 |pmid= 8995480 |doi=
*cite journal | author=Misra I, Griffith OW |title=Expression and purification of human gamma-glutamylcysteine synthetase. |journal=Protein Expr. Purif. |volume=13 |issue= 2 |pages= 268–76 |year= 1998 |pmid= 9675072 |doi= 10.1006/prep.1998.0897
*cite journal | author=Tu Z, Anders MW |title=Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis. |journal=Biochem. J. |volume=336 ( Pt 3) |issue= |pages= 675–80 |year= 1999 |pmid= 9841880 |doi=
*cite journal | author=Galloway DC, Blake DG, McLellan LI |title=Regulation of gamma-glutamylcysteine synthetase regulatory subunit (GLCLR) gene expression: identification of the major transcriptional start site in HT29 cells. |journal=Biochim. Biophys. Acta |volume=1446 |issue= 1-2 |pages= 47–56 |year= 1999 |pmid= 10395918 |doi=
*cite journal | author=Manna SK, Kuo MT, Aggarwal BB |title=Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1. |journal=Oncogene |volume=18 |issue= 30 |pages= 4371–82 |year= 1999 |pmid= 10439045 |doi= 10.1038/sj.onc.1202811
*cite journal | author=Beutler E, Gelbart T, Kondo T, Matsunaga AT |title=The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency. |journal=Blood |volume=94 |issue= 8 |pages= 2890–4 |year= 1999 |pmid= 10515893 |doi=
*cite journal | author=Ristoff E, Augustson C, Geissler J, "et al." |title=A missense mutation in the heavy subunit of gamma-glutamylcysteine synthetase gene causes hemolytic anemia. |journal=Blood |volume=95 |issue= 7 |pages= 2193–6 |year= 2000 |pmid= 10733484 |doi=
*cite journal | author=Yang H, Wang J, Ou X, "et al." |title=Cloning and analysis of the rat glutamate-cysteine ligase modifier subunit promoter. |journal=Biochem. Biophys. Res. Commun. |volume=285 |issue= 2 |pages= 476–82 |year= 2001 |pmid= 11444867 |doi= 10.1006/bbrc.2001.5190
*cite journal | author=Tatebe S, Sinicrope FA, Kuo MT |title=Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue= 5 |pages= 1427–33 |year= 2002 |pmid= 11820781 |doi= 10.1006/bbrc.2002.6367
*cite journal | author=Yang P, Yokomizo A, Tazelaar HD, "et al." |title=Genetic determinants of lung cancer short-term survival: the role of glutathione-related genes. |journal=Lung Cancer |volume=35 |issue= 3 |pages= 221–9 |year= 2002 |pmid= 11844594 |doi=
*cite journal | author=Ray S, Watkins DN, Misso NL, Thompson PJ |title=Oxidant stress induces gamma-glutamylcysteine synthetase and glutathione synthesis in human bronchial epithelial NCI-H292 cells. |journal=Clin. Exp. Allergy |volume=32 |issue= 4 |pages= 571–7 |year= 2002 |pmid= 11972604 |doi=

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