Rolf M. Zinkernagel

Rolf M. Zinkernagel

Infobox Scientist
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name = Rolf Martin Zinkernagel



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birth_date = birth date and age|1944|1|6|mf=yes
birth_place = Riehen, Basel-Stadt, Switzerland
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fields = immunology
workplaces = University of Zurich
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known_for = Cytotoxic T cells
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awards = Nobel Prize in Physiology or Medicine (1996)
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Rolf Martin Zinkernagel (January 6, 1944 in Riehen, Basel-Stadt, Switzerland) is Professor of Experimental Immunology at the University of Zurich.

Together with the Australian Peter C. Doherty he received the 1996 Nobel Prize in Physiology or Medicine for the discovery of how the immune system recognizes virus-infected cells. With this he became the 24th Swiss Nobel laureate.

Viruses infect host cells and reproduce inside them. Killer T-cells destroy those infected cells so that the viruses can't reproduce. Zinkernagel and Doherty discovered that, in order for killer T cells to recognize infected cells, they had to recognize two molecules on the surface of the cell -- not only the virus antigen, but also a molecule of the major histocompatibility complex (MHC). This recognition was done by a T-cell receptor on the surface of the T cell. The MHC was previously identified as being responsible for the rejection of incompatible tissues during transplantation. Zinkernagel and Dougherty discovered that the MHC was responsible for the body fighting meningitis viruses too. [ [http://nobelprize.org/nobel_prizes/medicine/laureates/1996/illpres/experiment.html The Nobel Prize in Physiology or Medicine 1996 -- Illustrated Presentation] ]

He received his MD from the University of Basel in 1970 and his PhD from the Australian National University in 1975. In addition to the Nobel Prize, he also won The Albert Lasker Medical Research Award in 1995.

References

External links

* [http://nobelprize.org/medicine/laureates/1996/zinkernagel-autobio.html Nobel Prize Autobiography]


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  • Rolf M. Zinkernagel — Rolf Martin Zinkernagel (* 6. Januar 1944 in Riehen, Basel Stadt) ist ein schweizerischer Mediziner und experimenteller Immunologe. Leben Zinkernagel studierte Medizin und promovierte 1970 an der Universität Basel. 1975 erhielt er den Ph. D. an… …   Deutsch Wikipedia

  • Rolf Martin Zinkernagel — (* 6. Januar 1944 in Riehen, Basel Stadt) ist ein schweizerischer Mediziner und experimenteller Immunologe. Leben Zinkernagel studierte Medizin und promovierte 1970 an der Universität Basel. 1975 erhielt er den Ph. D. an der Australian National… …   Deutsch Wikipedia

  • Rolf M. Zinkernagel — Saltar a navegación, búsqueda Rolf M. Zinkernagel nació en 1944 en Riehen Suiza. A finales de los años 60 comenzó a trabajar con Peter C. Doherty en Canberra Australia. En 1979 regresa a su país natal en donde ejerce como director del Instituto… …   Wikipedia Español

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  • Zinkernagel — Rolf Martin Zinkernagel (* 6. Januar 1944 in Riehen, Basel Stadt) ist ein schweizerischer Mediziner und experimenteller Immunologe. Leben Zinkernagel studierte Medizin und promovierte 1970 an der Universität Basel. 1975 erhielt er den Ph. D. an… …   Deutsch Wikipedia

  • Rolf Zinkernagel — Rolf Martin Zinkernagel (* 6. Januar 1944 in Riehen, Basel Stadt) ist ein Schweizer Mediziner und experimenteller Immunologe. Leben Zinkernagel studierte Medizin und promovierte 1970 an der Universität Basel. Er war Mitglied der Zofingia. 1975… …   Deutsch Wikipedia

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  • Zinkernagel, Rolf M. — ▪ Swiss scientist born Jan. 6, 1944, Basel, Switz.       Swiss immunologist and pathologist who, along with Peter C. Doherty (Doherty, Peter C.) of Australia, received the Nobel Prize for Physiology or Medicine in 1996 for their discovery of how… …   Universalium

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