DEK (gene)

DEK (gene)
DEK oncogene

PDB rendering based on 1q1v.
Identifiers
Symbols DEK; D6S231E
External IDs OMIM125264 MGI1926209 HomoloGene2593 GeneCards: DEK Gene
RNA expression pattern
PBB GE DEK 200934 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7913 110052
Ensembl ENSG00000124795 ENSMUSG00000021377
UniProt P35659 Q3U4W4
RefSeq (mRNA) NM_001134709.1 NM_025900.2
RefSeq (protein) NP_001128181.1 NP_080176.2
Location (UCSC) Chr 6:
18.22 – 18.27 Mb
Chr 13:
47.18 – 47.2 Mb
PubMed search [1] [2]

Protein DEK is a protein that in humans is encoded by the DEK gene.[1][2]

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.[2]

Interactions

DEK (gene) has been shown to interact with TFAP2A.[3]

References

Further reading


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