Tetraacyldisaccharide 4'-kinase

In enzymology, a tetraacyldisaccharide 4'-kinase (EC number|2.7.1.130) is an enzyme that catalyzes the chemical reaction

:ATP + [2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl] -(1->6)- [2- N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate] $ightleftharpoons$ ADP + [2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D- glucosaminyl] -(1->6)- [2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D- glucosaminyl phosphate]

The 3 substrates of this enzyme are ATP, [2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl] -(1->6)- [2-] , and N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate] , whereas its 4 products are ADP, [2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-, [glucosaminyl] -(1->6)- [2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-] , and glucosaminyl phosphate] .

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D -1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase. This enzyme is also called lipid-A 4'-kinase. This enzyme participates in lipopolysaccharide biosynthesis.

tructural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB link|2HF1.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|107309-06-8."

Gene Ontology (GO) codes