Adenylyl-sulfate kinase

In enzymology, an adenylyl-sulfate kinase (EC number|2.7.1.25) is an enzyme that catalyzes the chemical reaction

:ATP + adenylyl sulfate $ightleftharpoons$ ADP + 3'-phosphoadenylyl sulfate

Thus, the two substrates of this enzyme are ATP and adenylyl sulfate, whereas its two products are ADP and 3'-phosphoadenylyl sulfate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:adenylyl-sulfate 3'-phosphotransferase. Other names in common use include adenylylsulfate kinase (phosphorylating), 5'-phosphoadenosine sulfate kinase, adenosine 5'-phosphosulfate kinase, adenosine phosphosulfate kinase, adenosine phosphosulfokinase, adenosine-5'-phosphosulfate-3'-phosphokinase, and APS kinase. This enzyme participates in 3 metabolic pathways: purine metabolism, selenoamino acid metabolism, and sulfur metabolism.

tructural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1D6J, PDB link|1M7G, PDB link|1M7H, PDB link|1X6V, PDB link|1XJQ, PDB link|1XNJ, PDB link|2AX4, PDB link|2GKS, PDB link|2OFW, PDB link|2OFX, and PDB link|2PEY.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9012-38-8."

Gene Ontology (GO) codes