Mannosyl-3-phosphoglycerate synthase

Mannosyl-3-phosphoglycerate synthase
mannosyl-3-phosphoglycerate synthase
Identifiers
EC number 2.4.1.217
CAS number 393512-63-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a mannosyl-3-phosphoglycerate synthase (EC 2.4.1.217) is an enzyme that catalyzes the chemical reaction

GDP-mannose + 3-phospho-D-glycerate \rightleftharpoons GDP + 2-(alpha-D-mannosyl)-3-phosphoglycerate

Thus, the two substrates of this enzyme are GDP-mannose and 3-phospho-D-glycerate, whereas its two products are GDP and 2-(alpha-D-mannosyl)-3-phosphoglycerate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:3-phosphoglycerate 3-alpha-D-mannosyltransferase. This enzyme is also called MPG synthase.

References

  • Empadinhas N, Marugg JD, Borges N, Santos H, da Costa MS (2001). "Pathway for the synthesis of mannosylglycerate in the hyperthermophilic archaeon Pyrococcus horikoshii. Biochemical and genetic characterization of key enzymes". J. Biol. Chem. 276 (47): 43580–8. doi:10.1074/jbc.M108054200. PMID 11562374.