- Deoxyuridine phosphorylase
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deoxyuridine phosphorylase Identifiers EC number 2.4.2.23 CAS number 37277-77-3 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a deoxyuridine phosphorylase (EC 2.4.2.23) is an enzyme that catalyzes the chemical reaction
- 2'-deoxyuridine + phosphate
uracil + 2-deoxy-alpha-D-ribose 1-phosphate
Thus, the two substrates of this enzyme are 2'-deoxyuridine and phosphate, whereas its two products are uracil and 2-deoxy-alpha-D-ribose 1-phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is 2'-deoxyuridine:phosphate 2-deoxy-alpha-D-ribosyltransferase. This enzyme participates in pyrimidine metabolism.
References
- Soukhova-O'Hare GK, Roberts AM, Gozal D (2006). "Impaired control of renal sympathetic nerve activity following neonatal intermittent hypoxia in rats". Neurosci. Lett. 399 (3): 181–5. doi:10.1016/j.neulet.2006.01.054. PMID 16495004.
- Yamada EW (1964). "The effect of cortisol administration on the activities of uridine and deoxyuridine phosphorylases of normal and regenerating rat liver". Can. J. Biochem. 42: 317–325.
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