Glutamine-pyruvate transaminase

Glutamine-pyruvate transaminase

In enzymology, a glutamine-pyruvate transaminase (EC number|2.6.1.15) is an enzyme that catalyzes the chemical reaction

:L-glutamine + pyruvate ightleftharpoons 2-oxoglutaramate + L-alanine

Thus, the two substrates of this enzyme are L-glutamine and pyruvate, whereas its two products are 2-oxoglutaramate and L-alanine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:pyruvate aminotransferase. Other names in common use include glutaminase II, L-glutamine transaminase L, and glutamine-oxo-acid transaminase. This enzyme participates in glutamate metabolism. It employs one cofactor, pyridoxal phosphate.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1V2D, PDB link|1V2E, and PDB link|1V2F.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9030-44-8."

Gene Ontology (GO) codes


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