Adenosylmethionine-8-amino-7-oxononanoate transaminase

Adenosylmethionine-8-amino-7-oxononanoate transaminase

In enzymology, an adenosylmethionine-8-amino-7-oxononanoate transaminase (EC number|2.6.1.62) is an enzyme that catalyzes the chemical reaction

:S-adenosyl-L-methionine + 8-amino-7-oxononanoate ightleftharpoons S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and 8-amino-7-oxononanoate, whereas its two products are S-adenosyl-4-methylthio-2-oxobutanoate and 7,8-diaminononanoate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase. Other names in common use include 7,8-diaminonanoate transaminase, 7,8-diaminononanoate transaminase, DAPA transaminase, 7,8-diaminopelargonic acid aminotransferase, DAPA aminotransferase, 7-keto-8-aminopelargonic acid, diaminopelargonate synthase, and 7-keto-8-aminopelargonic acid aminotransferase. This enzyme participates in biotin metabolism. It employs one cofactor, pyridoxal phosphate.

tructural studies

As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DTY, PDB link|1MGV, PDB link|1MLY, PDB link|1MLZ, PDB link|1QJ3, PDB link|1QJ5, PDB link|1S06, PDB link|1S07, PDB link|1S08, PDB link|1S09, and PDB link|1S0A.

References

*
*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|37259-71-5."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”