- Geranyltranstransferase
In
enzymology , a geranyltranstransferase (EC number|2.5.1.10) is anenzyme that catalyzes thechemical reaction :geranyl diphosphate + isopentenyl diphosphate diphosphate + trans,trans-farnesyl diphosphate
Thus, the two substrates of this enzyme are
geranyl diphosphate andisopentenyl diphosphate , whereas its two products arediphosphate andtrans,trans-farnesyl diphosphate .This enzyme belongs to the family of
transferase s, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase. Other names in common use include farnesyl-diphosphate synthase, geranyl transferase I, prenyltransferase, farnesyl pyrophosphate synthetase, and farnesylpyrophosphate synthetase. This enzyme participates inbiosynthesis of steroids andterpenoid biosynthesis .tructural studies
As of late 2007, 25 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1FPS, PDB link|1RQI, PDB link|1RQJ, PDB link|1YHK, PDB link|1YHM, PDB link|1YQ7, PDB link|1YV5, PDB link|1ZW5, PDB link|2EWG, PDB link|2F7M, PDB link|2F89, PDB link|2F8C, PDB link|2F8Z, PDB link|2F92, PDB link|2F94, PDB link|2F9K, PDB link|2FOR, PDB link|2FTZ, PDB link|2H8O, PDB link|2I19, PDB link|2OGD, PDB link|2OPN, PDB link|2Q80, PDB link|2QIS, and PDB link|2RAH.
References
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*External links
::"The
CAS registry number for this enzyme class is CAS registry|37277-79-5."Gene Ontology (GO) codes
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