Cysteine-S-conjugate N-acetyltransferase

Cysteine-S-conjugate N-acetyltransferase
cysteine-S-conjugate N-acetyltransferase
Identifiers
EC number 2.3.1.80
CAS number 81725-80-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a cysteine-S-conjugate N-acetyltransferase (EC 2.3.1.80) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an S-substituted L-cysteine \rightleftharpoons CoA + an S-substituted N-acetyl-L-cysteine

Thus, the two substrates of this enzyme are acetyl-CoA and S-substituted L-cysteine, whereas its two products are CoA and S-substituted N-acetyl-L-cysteine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:S-substituted L-cysteine N-acetyltransferase. This enzyme participates in glutathione metabolism.

References

  • Duffel MW, Jakoby WB (1982). "Cysteine S-conjugate N-acetyltransferase from rat kidney microsomes". Mol. Pharmacol. 21 (2): 444–8. PMID 6892478. 
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