Choloyl-CoA hydrolase

Choloyl-CoA hydrolase
Choloyl-CoA hydrolase
Identifiers
EC number 3.1.2.27
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a choloyl-CoA hydrolase (EC 3.1.2.27) is an enzyme that catalyzes the chemical reaction

choloyl-CoA + H2O \rightleftharpoons cholate + CoA

Thus, the two substrates of this enzyme are choloyl-CoA and H2O, whereas its two products are cholate and CoA.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is choloyl-CoA hydrolase. Other names in common use include PTE-2 (ambiguous), choloyl-coenzyme A thioesterase, chenodeoxycholoyl-coenzyme A thioesterase, and peroxisomal acyl-CoA thioesterase 2.

References

  • Hunt MC, Solaas K, Kase BF, Alexson SE (2002). "Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism". J. Biol. Chem. 277 (2): 1128–38. doi:10.1074/jbc.M106458200. PMID 11673457. 
  • Solaas K, Sletta RJ, Soreide O, Kase BF (2000). "Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver". Scand. J. Clin. Lab. Invest. 60 (2): 91–102. doi:10.1080/00365510050184903. PMID 10817395. 
  • Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708. 
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