Derrubone

Derrubone
Derrubone
Identifiers
ChEMBL CHEMBL412010 N
Properties
Molecular formula C21H18O6
Molar mass 366.37 g/mol
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Derrubone is an isoflavone, a type of flavonoid. It bears a prenyl acetylation. It was originally isolated from the Indian tree Derris robusta.[1] Recent research indicates that it acts as an inhibitor of Hsp90 to its function as a chaperone protein.[2]

References

  1. ^ East AJ, Ollis WD, Wheeler RE (1969). "Natural occurrence of 3-aryl-4-hydroxycoumarins. Part I. Phytochemical examination of Derris robusta(roxb.) benth.". J. Chem. Soc. C 3: 365–74. doi:10.1039/J39690000365. http://www.rsc.org/publishing/journals/J3/article.asp?doi=J39690000365. 
  2. ^ Hadden MK, Galam L, Gestwicki JE, Matts RL, Blagg BS (December 2007). "Derrubone, an inhibitor of the Hsp90 protein folding machinery". J. Nat. Prod. 70 (12): 2014–8. doi:10.1021/np070190s. PMID 18020309. 
v · glycosides
Isoflavones
Daidzein | Genistein | Irilone |Orobol | Pseudobaptigenin | Anagyroidisoflavone A and B
O-methylated isoflavones
Biochanin A | Calycosin | Formononetin | Glycitein | Irigenin | 5-O-methylgenistein | Pratensein | Prunetin | Psi-tectorigenin | Retusin | Tectorigenin
Glycosides
Daidzin | Genistin | Iridin | Ononin | Puerarin | Tectoridin
Prenylated isoflavones
Bidwillol A | Derrubone | Luteone | Wighteone
Pyranoisoflavones
Alpinumisoflavone | Barbigerone | Di-O-methylalpinumisoflavone | 4'-methyl-alpinumisoflavone
Misc
Rotenoids
Synthetic
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