- Citramalyl-CoA lyase
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citramalyl-CoA lyase Identifiers EC number 4.1.3.25 CAS number 37290-68-9 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a citramalyl-CoA lyase (EC 4.1.3.25) is an enzyme that catalyzes the chemical reaction
- (3S)-citramalyl-CoA
acetyl-CoA + pyruvate
Hence, this enzyme has one substrate, (3S)-citramalyl-CoA, and two products, acetyl-CoA and pyruvate.
This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming). Other names in common use include citramalyl coenzyme A lyase, (+)-CMA-CoA lyase, and (3S)-citramalyl-CoA pyruvate-lyase. This enzyme participates in pyruvate metabolism and c5-branched dibasic acid metabolism.
References
- Cooper RA, Kornberg HL (1964). "The utilization of itaconate by Pseudomonas sp". Biochem. J. 91 (1): 82–91. PMC 1202819. PMID 4284209. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1202819.
- Dimroth P, Buckel W, Loyal R, Eggerer H (1977). "Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase". Eur. J. Biochem. 80 (2): 469–77. doi:10.1111/j.1432-1033.1977.tb11902.x. PMID 923590.
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