Chorismate lyase

Chorismate lyase
Identifiers
EC number	4.1.3.40
CAS number	157482-18-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles

Chorismate lyase
chorismate lyase with product, 1.0 a resolution
Identifiers
Symbol	Chor_lyase
Pfam	PF04345
Pfam clan	CL0122
InterPro	IPR007440
SCOP	1jd3
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

In enzymology, a chorismate lyase (EC 4.1.3.40) is an enzyme that catalyzes the chemical reaction

chorismate $\rightleftharpoons$ 4-hydroxybenzoate + pyruvate

Hence, this enzyme has one substrate, chorismate, and two products, 4-hydroxybenzoate and pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is chorismate pyruvate-lyase (4-hydroxybenzoate-forming). Other names in common use include CL, CPL, and UbiC.

This enzyme catalyses the first step in ubiquinone biosynthesis, the removal of pyruvate from chorismate, to yield 4-hydroxybenzoate in Escherichia coli and other Gram-negative bacteria.^[1] Its activity does not require metal cofactors.^[2]

References

1. ^ Nichols BP, Green JM (August 1992). "Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase". J. Bacteriol. 174 (16): 5309–16. PMC 206367. PMID 1644758. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=206367. 
2. ^ Siebert M, Severin K, Heide L (April 1994). "Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase". Microbiology (Reading, Engl.) 140 ( Pt 4): 897–904. doi:10.1099/00221287-140-4-897. PMID 8012607. 

Further reading

• Nichols BP, Green JM (1992). "Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase". J. Bacteriol. 174 (16): 5309–16. PMC 206367. PMID 1644758. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=206367. 
• Siebert M, Severin K, Heide L (Pt 4). "Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase". Microbiology. 140 (4): 897–904. doi:10.1099/00221287-140-4-897. PMID 8012607. 
• Meganathan R (2001). "Ubiquinone biosynthesis in microorganisms". FEMS. Microbiol. Lett. 203 (2): 131–9. doi:10.1111/j.1574-6968.2001.tb10831.x. PMID 11583838. 

This article includes text from the public domain Pfam and InterPro IPR007440

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