Xylose isomerase

Xylose isomerase
xylose isomerase
Identifiers
EC number 5.3.1.5
CAS number 9023-82-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a xylose isomerase (EC 5.3.1.5) is an enzyme that catalyzes the chemical reaction

D-xylose \rightleftharpoons D-xylulose

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is D-xylose aldose-ketose-isomerase. Other names in common use include D-xylose isomerase, D-xylose ketoisomerase, and D-xylose ketol-isomerase. This enzyme participates in pentose and glucuronate interconversions and fructose and mannose metabolism. The enzyme is used industrially to convert glucose to fructose in the manufacture of high-fructose corn syrup. It is sometimes referred to as "glucose isomerase".

Structural studies

As of late 2007, 73 structures have been solved for this class of enzymes, with PDB accession codes 1A0C, 1A0D, 1A0E, 1BHW, 1BXB, 1BXC, 1CLK, 1DID, 1DIE, 1DXI, 1GW9, 1MNZ, 1MUW, 1O1H, 1OAD, 1QT1, 1S5M, 1S5N, 1XIA, 1XIB, 1XIC, 1XID, 1XIE, 1XIF, 1XIG, 1XIH, 1XII, 1XIJ, 1XIM, 1XIN, 1XIS, 1XLA, 1XLB, 1XLC, 1XLD, 1XLE, 1XLF, 1XLG, 1XLH, 1XLI, 1XLJ, 1XLK, 1XLL, 1XLM, 1XYA, 1XYB, 1XYC, 1XYL, 1XYM, 2G4J, 2GLK, 2GUB, 2GVE, 2GYI, 2XIM, 2XIN, 2XIS, 3XIM, 3XIN, 3XIS, 4XIA, 4XIM, 4XIS, 5XIA, 5XIM, 5XIN, 6XIA, 6XIM, 7XIM, 8XIA, 8XIM, 9XIA, and 9XIM.

References

  • HOCHSTER RM, WATSON RW (1954). "Enzymatic isomerization of D-xylose to D-xylulose". Arch. Biochem. Biophys. 48 (1): 120–9. doi:10.1016/0003-9861(54)90313-6. PMID 13125579. 
  • Slein MW (1955). "Xylose isomerase from Pasteurella pestis, strain A-1122". J. Am. Chem. Soc. 77 (6): 1663–1667. doi:10.1021/ja01611a074. 
  • Yamanaka K (1968). "Purification, crystallization and properties of the D-xylose isomerase from Lactobacillus brevis". Biochim. Biophys. Acta. 151 (3): 670–80. PMID 5646045. 
This isomerase article is a stub. You can help Wikipedia by expanding it.