Steroid Delta-isomerase

In enzymology, a steroid Delta-isomerase (EC number|5.3.3.1) is an enzyme that catalyzes the chemical reaction

:a 3-oxo-Delta₅-steroid $ightleftharpoons$ a 3-oxo-Delta₄-steroid

Hence, this enzyme has one substrate, 3-oxo-Delta5-steroid, and one product, 3-oxo-Delta4-steroid.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is 3-oxosteroid Delta5-Delta4-isomerase. Other names in common use include hydroxysteroid isomerase, steroid isomerase, Delta5-ketosteroid isomerase, Delta5(or Delta4)-3-keto steroid isomerase, Delta5-steroid isomerase, 3-oxosteroid isomerase, Delta5-3-keto steroid isomerase, and Delta5-3-oxosteroid isomerase. This enzyme participates in c21-steroid hormone metabolism and androgen and estrogen metabolism.

tructural studies

As of late 2007, 25 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BUQ, PDB link|1C7H, PDB link|1CQS, PDB link|1DMM, PDB link|1DMN, PDB link|1DMQ, PDB link|1E97, PDB link|1GS3, PDB link|1ISK, PDB link|1K41, PDB link|1OCV, PDB link|1OGX, PDB link|1OGZ, PDB link|1OH0, PDB link|1OHO, PDB link|1OHP, PDB link|1OHS, PDB link|1OPY, PDB link|1VZZ, PDB link|1W00, PDB link|1W01, PDB link|1W02, PDB link|1W6Y, PDB link|2PZV, and PDB link|8CHO.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9031-36-1."

Gene Ontology (GO) codes