LCP1

Lymphocyte cytosolic protein 1 (L-plastin), also known as LCP1, is a human gene.

PBB_Summary
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summary_text = Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.cite web | title = Entrez Gene: LCP1 lymphocyte cytosolic protein 1 (L-plastin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3936| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Namba Y, Ito M, Zu Y, "et al." |title=Human T cell L-plastin bundles actin filaments in a calcium-dependent manner. |journal=J. Biochem. |volume=112 |issue= 4 |pages= 503–7 |year= 1993 |pmid= 1491005 |doi=
*cite journal | author=Zu Y, Kohno M, Kubota I, "et al." |title=Characterization of interleukin 2 stimulated 65-kilodalton phosphoprotein in human T cells. |journal=Biochemistry |volume=29 |issue= 4 |pages= 1055–62 |year= 1990 |pmid= 2111166 |doi=
*cite journal | author=Zu YL, Shigesada K, Nishida E, "et al." |title=65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites. |journal=Biochemistry |volume=29 |issue= 36 |pages= 8319–24 |year= 1991 |pmid= 2252891 |doi=
*cite journal | author=Lin CS, Aebersold RH, Leavitt J |title=Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain. |journal=Mol. Cell. Biol. |volume=10 |issue= 4 |pages= 1818–21 |year= 1990 |pmid= 2378651 |doi=
*cite journal | author=Lin CS, Aebersold RH, Kent SB, "et al." |title=Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts. |journal=Mol. Cell. Biol. |volume=8 |issue= 11 |pages= 4659–68 |year= 1989 |pmid= 3211125 |doi=
*cite journal | author=Matsushima K, Shiroo M, Kung HF, Copeland TD |title=Purification and characterization of a cytosolic 65-kilodalton phosphoprotein in human leukocytes whose phosphorylation is augmented by stimulation with interleukin 1. |journal=Biochemistry |volume=27 |issue= 10 |pages= 3765–70 |year= 1988 |pmid= 3261603 |doi=
*cite journal | author=Kondo I, Shin K, Honmura S, "et al." |title=A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13. |journal=Hum. Genet. |volume=71 |issue= 3 |pages= 263–6 |year= 1986 |pmid= 3864729 |doi=
*cite journal | author=Arpin M, Friederich E, Algrain M, "et al." |title=Functional differences between L- and T-plastin isoforms. |journal=J. Cell Biol. |volume=127 |issue= 6 Pt 2 |pages= 1995–2008 |year= 1995 |pmid= 7806577 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Lin CS, Shen W, Chen ZP, "et al." |title=Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2457–67 |year= 1994 |pmid= 8139549 |doi=
*cite journal | author=Lin CS, Park T, Chen ZP, Leavitt J |title=Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2781–92 |year= 1993 |pmid= 8428952 |doi=
*cite journal | author=Lin CS, Chen ZP, Park T, "et al." |title=Characterization of the human L-plastin gene promoter in normal and neoplastic cells. |journal=J. Biol. Chem. |volume=268 |issue= 4 |pages= 2793–801 |year= 1993 |pmid= 8428953 |doi=
*cite journal | author=Jones SL, Brown EJ |title=FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils. |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14623–30 |year= 1996 |pmid= 8663066 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Okumura Y, Yano M, Murakami M, "et al." |title=The extracellular processing of HIV-1 envelope glycoprotein gp160 by human plasmin. |journal=FEBS Lett. |volume=442 |issue= 1 |pages= 39–42 |year= 1999 |pmid= 9923600 |doi=
*cite journal | author=Wang J, Brown EJ |title=Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 24349–56 |year= 1999 |pmid= 10446213 |doi=
*cite journal | author=Lin CS, Lau A, Yeh CC, "et al." |title=Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences. |journal=DNA Cell Biol. |volume=19 |issue= 1 |pages= 1–7 |year= 2000 |pmid= 10668786 |doi= 10.1089/104454900314654
*cite journal | author=Jia J, Han Q, Borregaard N, "et al." |title=Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. |journal=J. Mol. Biol. |volume=300 |issue= 5 |pages= 1271–81 |year= 2000 |pmid= 10903868 |doi= 10.1006/jmbi.2000.3925
*cite journal | author=Lollike K, Johnsen AH, Durussel I, "et al." |title=Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 17762–9 |year= 2001 |pmid= 11279160 |doi= 10.1074/jbc.M100965200
*cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, "et al." |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101

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