ANXA6

Annexin A6, also known as ANXA6, is a human gene.

PBB_Summary
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summary_text = Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Exon 21 of annexin VI is alternatively spliced, giving rise to two isoforms that differ by a 6-amino acid insertion at the start of the seventh repeat. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis.cite web | title = Entrez Gene: ANXA6 annexin A6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=309| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Moss SE, Jacob SM, Davies AA, Crumpton MJ |title=A growth-dependent post-translational modification of annexin VI. |journal=Biochim. Biophys. Acta |volume=1160 |issue= 1 |pages= 120–6 |year= 1992 |pmid= 1420329 |doi=
*cite journal | author=Barel M, Gauffre A, Lyamani F, "et al." |title=Intracellular interaction of EBV/C3d receptor (CR2) with p68, a calcium-binding protein present in normal but not in transformed B lymphocytes. |journal=J. Immunol. |volume=147 |issue= 4 |pages= 1286–91 |year= 1991 |pmid= 1831222 |doi=
*cite journal | author=Yoshizaki H, Mizoguchi T, Arai K, "et al." |title=Structure and properties of calphobindin II, an anticoagulant protein from human placenta. |journal=J. Biochem. |volume=107 |issue= 1 |pages= 43–50 |year= 1990 |pmid= 2139657 |doi=
*cite journal | author=Iwasaki A, Suda M, Watanabe M, "et al." |title=Structure and expression of cDNA for calphobindin II, a human placental coagulation inhibitor. |journal=J. Biochem. |volume=106 |issue= 1 |pages= 43–9 |year= 1989 |pmid= 2528541 |doi=
*cite journal | author=Davies AA, Moss SE, Crompton MR, "et al." |title=The gene coding for the p68 calcium-binding protein is localised to bands q32-q34 of human chromosome 5, and to mouse chromosome 11. |journal=Hum. Genet. |volume=82 |issue= 3 |pages= 234–8 |year= 1989 |pmid= 2731935 |doi=
*cite journal | author=Südhof TC, Slaughter CA, Leznicki I, "et al." |title=Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 3 |pages= 664–8 |year= 1988 |pmid= 2963335 |doi=
*cite journal | author=Crompton MR, Owens RJ, Totty NF, "et al." |title=Primary structure of the human, membrane-associated Ca2+-binding protein p68 a novel member of a protein family. |journal=EMBO J. |volume=7 |issue= 1 |pages= 21–7 |year= 1988 |pmid= 3258820 |doi=
*cite journal | author=Warrington JA, Bengtsson U |title=High-resolution physical mapping of human 5q31-q33 using three methods: radiation hybrid mapping, interphase fluorescence in situ hybridization, and pulsed-field gel electrophoresis. |journal=Genomics |volume=24 |issue= 2 |pages= 395–8 |year= 1995 |pmid= 7698768 |doi= 10.1006/geno.1994.1636
*cite journal | author=Barel M, Balbo M, Gauffre A, Frade R |title=Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein. |journal=Mol. Immunol. |volume=32 |issue= 6 |pages= 389–97 |year= 1995 |pmid= 7753047 |doi=
*cite journal | author=Smith PD, Davies A, Crumpton MJ, Moss SE |title=Structure of the human annexin VI gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 7 |pages= 2713–7 |year= 1994 |pmid= 8146179 |doi=
*cite journal | author=Benz J, Bergner A, Hofmann A, "et al." |title=The structure of recombinant human annexin VI in crystals and membrane-bound. |journal=J. Mol. Biol. |volume=260 |issue= 5 |pages= 638–43 |year= 1996 |pmid= 8709144 |doi= 10.1006/jmbi.1996.0426
*cite journal | author=Davis AJ, Butt JT, Walker JH, "et al." |title=The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24333–6 |year= 1996 |pmid= 8798684 |doi=
*cite journal | author=Barwise JL, Walker JH |title=Annexins II, IV, V and VI relocate in response to rises in intracellular calcium in human foreskin fibroblasts. |journal=J. Cell. Sci. |volume=109 ( Pt 1) |issue= |pages= 247–55 |year= 1996 |pmid= 8834809 |doi=
*cite journal | author=Kester HA, van der Leede BM, van der Saag PT, van der Burg B |title=Novel progesterone target genes identified by an improved differential display technique suggest that progestin-induced growth inhibition of breast cancer cells coincides with enhancement of differentiation. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16637–43 |year= 1997 |pmid= 9195978 |doi=
*cite journal | author=Song G, Campos B, Wagoner LE, "et al." |title=Altered cardiac annexin mRNA and protein levels in the left ventricle of patients with end-stage heart failure. |journal=J. Mol. Cell. Cardiol. |volume=30 |issue= 3 |pages= 443–51 |year= 1998 |pmid= 9515022 |doi= 10.1006/jmcc.1997.0608
*cite journal | author=Garbuglia M, Verzini M, Donato R |title=Annexin VI binds S100A1 and S100B and blocks the ability of S100A1 and S100B to inhibit desmin and GFAP assemblies into intermediate filaments. |journal=Cell Calcium |volume=24 |issue= 3 |pages= 177–91 |year= 1999 |pmid= 9883272 |doi=
*cite journal | author=Chow A, Gawler D |title=Mapping the site of interaction between annexin VI and the p120GAP C2 domain. |journal=FEBS Lett. |volume=460 |issue= 1 |pages= 166–72 |year= 1999 |pmid= 10571081 |doi=
*cite journal | author=Dieudonné SC, Kerr JM, Xu T, "et al." |title=Differential display of human marrow stromal cells reveals unique mRNA expression patterns in response to dexamethasone. |journal=J. Cell. Biochem. |volume=76 |issue= 2 |pages= 231–43 |year= 2000 |pmid= 10618640 |doi=
*cite journal | author=Pfander D, Swoboda B, Kirsch T |title=Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes. |journal=Am. J. Pathol. |volume=159 |issue= 5 |pages= 1777–83 |year= 2001 |pmid= 11696438 |doi=
*cite journal | author=Takagi H, Asano Y, Yamakawa N, "et al." |title=Annexin 6 is a putative cell surface receptor for chondroitin sulfate chains. |journal=J. Cell. Sci. |volume=115 |issue= Pt 16 |pages= 3309–18 |year= 2003 |pmid= 12140262 |doi=

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