SUMO2

SUMO2

SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae), also known as SUMO2, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.cite web | title = Entrez Gene: SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6613| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Mannen H, Tseng HM, Cho CL, Li SS |title=Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 1 |pages= 178–80 |year= 1996 |pmid= 8630065 |doi= 10.1006/bbrc.1996.0717
*cite journal | author=Lapenta V, Chiurazzi P, van der Spek P, "et al." |title=SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. |journal=Genomics |volume=40 |issue= 2 |pages= 362–6 |year= 1997 |pmid= 9119407 |doi= 10.1006/geno.1996.4556
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Kamitani T, Nguyen HP, Kito K, "et al." |title=Covalent modification of PML by the sentrin family of ubiquitin-like proteins. |journal=J. Biol. Chem. |volume=273 |issue= 6 |pages= 3117–20 |year= 1998 |pmid= 9452416 |doi=
*cite journal | author=Kamitani T, Kito K, Nguyen HP, "et al." |title=Characterization of a second member of the sentrin family of ubiquitin-like proteins. |journal=J. Biol. Chem. |volume=273 |issue= 18 |pages= 11349–53 |year= 1998 |pmid= 9556629 |doi=
*cite journal | author=Saitoh H, Hinchey J |title=Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6252–8 |year= 2000 |pmid= 10692421 |doi=
*cite journal | author=Nishida T, Tanaka H, Yasuda H |title=A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase. |journal=Eur. J. Biochem. |volume=267 |issue= 21 |pages= 6423–7 |year= 2000 |pmid= 11029585 |doi=
*cite journal | author=Dai KS, Liew CC |title=A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23992–9 |year= 2001 |pmid= 11283016 |doi= 10.1074/jbc.M011208200
*cite journal | author=Tatham MH, Jaffray E, Vaughan OA, "et al." |title=Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. |journal=J. Biol. Chem. |volume=276 |issue= 38 |pages= 35368–74 |year= 2001 |pmid= 11451954 |doi= 10.1074/jbc.M104214200
*cite journal | author=Nishida T, Kaneko F, Kitagawa M, Yasuda H |title=Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39060–6 |year= 2001 |pmid= 11489887 |doi= 10.1074/jbc.M103955200
*cite journal | author=Hardeland U, Steinacher R, Jiricny J, Schär P |title=Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. |journal=EMBO J. |volume=21 |issue= 6 |pages= 1456–64 |year= 2002 |pmid= 11889051 |doi= 10.1093/emboj/21.6.1456
*cite journal | author=Kim J, Cantwell CA, Johnson PF, "et al." |title=Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38037–44 |year= 2002 |pmid= 12161447 |doi= 10.1074/jbc.M207235200
*cite journal | author=Su HL, Li SS |title=Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. |journal=Gene |volume=296 |issue= 1-2 |pages= 65–73 |year= 2003 |pmid= 12383504 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Petrie K, Guidez F, Howell L, "et al." |title=The histone deacetylase 9 gene encodes multiple protein isoforms. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 16059–72 |year= 2003 |pmid= 12590135 |doi= 10.1074/jbc.M212935200
*cite journal | author=Hietakangas V, Ahlskog JK, Jakobsson AM, "et al." |title=Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2953–68 |year= 2003 |pmid= 12665592 |doi=
*cite journal | author=Eaton EM, Sealy L |title=Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 33416–21 |year= 2003 |pmid= 12810706 |doi= 10.1074/jbc.M305680200
*cite journal | author=Tatham MH, Kim S, Yu B, "et al." |title=Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. |journal=Biochemistry |volume=42 |issue= 33 |pages= 9959–69 |year= 2003 |pmid= 12924945 |doi= 10.1021/bi0345283
*cite journal | author=Chung TL, Hsiao HH, Yeh YY, "et al." |title=In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39653–62 |year= 2004 |pmid= 15272016 |doi= 10.1074/jbc.M405637200

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