Pteridine reductase

In enzymology, a pteridine reductase (EC number|1.5.1.33) is an enzyme that catalyzes the chemical reaction

:5,6,7,8-tetrahydrobiopterin + 2 NADP⁺ $ightleftharpoons$ biopterin + 2 NADPH + 2 H⁺

Thus, the two substrates of this enzyme are 5,6,7,8-tetrahydrobiopterin and NADP⁺, whereas its 3 products are biopterin, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydrobiopterin:NADP+ oxidoreductase. Other names in common use include PTR1, and pteridine reductase 1.

tructural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1W0C, PDB link|2BF7, PDB link|2BFA, PDB link|2BFM, PDB link|2BFO, PDB link|2BFP, and PDB link|2C7V.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|131384-61-7."